清固方对抗磷脂抗体综合征受孕小鼠ACA及胚胎吸收率的影响  

Effect of Formula of Qing-gu on ACA and Embryo Absorption Rate in Pregnant Mice with Positive Anti-phospholipid Antibody(APLA)

作　　者：吴菲[1] 高祥福[2] 

机构地区：[1]浙江中医药大学 [2]浙江中医药大学第三附属医院

出　　处：《山西中医》2014年第1期50-51,57,共3页Shanxi Journal of Traditional Chinese Medicine

基　　金：浙江省自然科学基金项目(编号:64212036)

摘　　要：目的:观察清固方对抗磷脂抗体阳性受孕小鼠抗心磷脂抗体(ACA)、胚胎吸收率的影响。方法:通过建立β_2糖蛋白Ⅰ(β_2 GPI)所致小鼠体内产生抗磷脂综合征的模型,观察中药复方清固方对抗磷脂抗体阳性抗磷脂综合征受孕小鼠ACA、胚胎吸收率的影响。结果:清固方对小鼠体内ACA、胚胎吸收率有明显的降低作用,并呈剂量相关性。结论:清固方能够有效降低抗磷脂综合征受孕小鼠体内的ACA、胚胎吸收率水平,并抑制抗磷脂抗体的产生及其对胚胎的损害,从而达到保胎的目的。Objective ： To observe the effect of Formula of Qing-gu on anticardiolipin antibody （ACA） and em- bryo absorption rate in pregnant mice with positive anti-phospholipid antibody （APLA）. Methods： The model of antiphospholipid syndrome was made up with β2 glycoprotein I （152GPI）. Then anticardiolipin antibody （ACA） and embryo absorption rate were observed after treatment with Formula of Qing-gu. Results： Formula of Qing-gu decreased ACA and embryo absorption rate on mice, which showed dosage associativity. Conclusion： Formula of Qing-gu can effectively reduce ACA and embryo absorption rate in pregnant mice with positive anti-phospholipid antibody, and inhibit the generation of antiphospholipid antibodies and its harm to embryos so as to achieve the purpose of protecting embryo （tocolysis）.

关 键 词：抗磷脂抗体综合征 清固方 抗心磷脂抗体 胚胎吸收率 实验研究 

分 类 号：R285[医药卫生—中药学] R715[医药卫生—中医学]