盐酸奥昔布宁制剂品种开发  

Development of oxybutynin hydrocholoride formulations

作　　者：王雪 周斌 王浩 罗华菲 

机构地区：[1]中国医药工业研究总院药物制剂国家工程中心,上海201203 [2]中国医药工业研究总院,上海200040

出　　处：《世界临床药物》2014年第1期54-59,共6页World Clinical Drug

摘　　要：盐酸奥昔布宁广泛用于治疗膀胱活动过度症。为克服服用本品后所产生的耐受性及顺应性问题,其经历了从速释制剂、缓释制剂、透皮贴剂到透皮凝胶的发展历程。本文综述目前美国食品药品管理局(FDA)批准上市的各种盐酸奥昔布宁制剂,并对其给药系统、药动学、临床有效性及安全性进行总结及比较。Oxybutynin hydrochloride has been widely used for treating overactive bladder. For the improvement on tolerability and compliance, a variety of oxybutynin formulations including immediate release pills, extended release tablets, transdemal patehs and topical gels have been developed. This review describes various oxybutynin formulations approved by FDA, and evaluates their drug delivery system, pharmacokineties, clinical effcaey and safety.

关 键 词：盐酸奥昔布宁 速释 缓释 透皮贴剂 透皮凝胶 

分 类 号：R983[医药卫生—药品] R694.5[医药卫生—药学]