红霉素联合阿奇霉素序贯疗法在小儿支原体肺炎治疗中的应用分析  

Application analysis on the sequential therapy of erythromycin combined with azithromycin for Mycoplasma pneumonia in children

作　　者：周雄飞[1] 郑君 毛开新[1] 

机构地区：[1]湖北科技学院临床医学院,咸宁437100 [2]湖北省咸宁市第一人民医院,湖北咸宁437000

出　　处：《中国当代医药》2014年第2期70-71,74,共3页China Modern Medicine

摘　　要：目的分析红霉素联合阿奇霉素序贯疗法在小儿支原体肺炎治疗中的应用价值。方法随机抽取2009年11月～2012年11月来本院儿科门诊就诊并确诊为小儿支原体肺炎的患儿96例，均给予常规退热、镇咳和祛痰治疗，其中48例患儿应用红霉素联合阿奇霉素序贯疗法为联合治疗组，其余48例患儿应用阿奇霉素序贯疗法为常规治疗组。统计两组患儿治疗的总成功率、各项临床指标的改善效果以及各种不良反应的发生率，评价红霉素联合阿奇霉素序贯疗法在小儿支原体肺炎治疗中的应用价值。结果联合治疗组患儿治疗的总成功率为97．92％，常规治疗组治疗的总成功率为85．42％（P〈0．05）。联合治疗组患儿退热时间、咳嗽消失时间、哕音消失时间以及平均住院时间均明显短于常规治疗组（P〈O．05）。联合治疗组患儿治疗过程中，各项不良反应发生率明显低于常规治疗组（P〈O．05）。结论红霉素联合阿奇霉素序贯疗法治疗小儿支原体肺炎成功率高、起效快、不良反廊少．比单纯阿奇霉素序贯疗法可具有特异件．Objective To anlyze the application value of the sequential therapy of erythromycin combined with azithromycin for Mycoplasma pneumonia in children.Methods 96 cases of children patients admitted to our hospital from November 2009 to November 2012 and diagnosed as Mycoplasma pneumonia in children were selected randomly and divided into the combination group （n=48） and the general group （n=48）.All these patients were given conventional fever,relieving cough and eliminating expectoration.The combination group was given the sequential therapy of erythromycin combined with azithromycin,while the general group was given the sequential therapy of azithromycin.The effective rate of thera- py,each clinical index and the incidence of every adverse reaction was calculated,and the application value of the se- quential therapy of erythromycin combined with azithromycin for Mycoplasma pneumonia in children was evaluated. Results The total success rate of the combination group was 97.92% which was significantly higher than 85.42% of the general group （P〈0.05）.The time of abating fever,the time of cough disappeared,the time of tale disappeared and aver- age hospitalization time in the combination group was significantly shorten than that in the general group （P〈0.05）.The incidence of every adverse reaction in the combination group was significantly lower than that in the general group （P〈 0.05）.Conclusion The sequential therapy of erythromycin combined with azithromycin for Mycoplasma pneumonia in children has the characters of high efficiency,rapid effect and low incidence of every adverse reaction which has higher specificity than the sequential therapy of only azithromycin,and should be applied in clinic.

关 键 词：红霉素 阿奇霉素 序贯疗法 小儿支原体肺炎 

分 类 号：R974[医药卫生—药品]