严重烧伤患者TNF、IL-6和IL-8水平的变化及相关性研究  

Changes of TNF,IL-6 and IL-8 levels in patients with severe burn

作　　者：陈晓东[1] 吴伯瑜[1] 王顺宾[1] 江琼[1] 黄逢元[1] 

机构地区：[1]福建医科大学附属协和医院省烧伤研究所,福州350001

出　　处：《急诊医学》2000年第6期387-388,共2页

摘　　要：目的 :研究烧伤后细胞因子的变化规律及其相关性 ,并探讨其临床意义。方法 :采用放射免疫法和ELISA法检测烧伤患者血中TNF、IL 6及IL 8水平。结果 :烧伤后血中TNF、IL 6及IL 8水平均显著高于正常对照组 (P <0 0 0 1) ,且持续时间较长 (4～ 5周 ) ,它们间呈正相关 (P <0 0 1) ;同时 ,IL 6与烧伤总面积呈正相关。结论 :细胞因子活性的检测有助于病情的评估及预后判断 ,尤其是大面积烧伤患者。Objective:To investigate the changes of cytokines and tle clinical significancl in patients with burns.Methods:RIA and ELISA methods were used to determine the TNF,IL 6 and IL 8 levels in burn patiants.Results:Levels of TNF,IL 6 and IL 8 in burn patients were significantly greater than normal controls(P<0 001),and this was prolonged (4～5weeks).There were significant positive correlations(P<0 01) among TNF and IL 6,TNF and IL 8,and IL 6 and IL 8,and a significantly positive correlation between serum levels of IL 6 and total burn surface area.Conclusion:The assay of TNF,IL 6 and IL 8 levels may be helpful for evaluating patients and the prognosis,particularly for those wih extensive deep burns.

关 键 词：烧伤 TNF IL-6 IL-8 相关性 

分 类 号：R644[医药卫生—外科学]