动力性主动脉瓣研究近况  

Recent Advance in Studies of New Intraaortic Axial Flow Pump:“Dynamic Aortic Valve”

作　　者：李国荣[1] 马维国[1] 胡盛寿[1] 赵红[1] 朱晓东[1] 吴清玉[1] 任兵[1] 赵康丽[1] 

机构地区：[1]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院外科瓣膜及辅助循环研究室,北京100037

出　　处：《生物医学工程学杂志》2000年第4期407-407,共1页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(39870732)

摘　　要：我们曾提出植入式左心辅助装置的一种新设想—动力性主动脉瓣。将一螺旋浆式叶轮植入到主动脉瓣位置主动旋转 ,在输入不同功率的条件下分别发挥机械性瓣膜或辅助性血泵两种不同的功能。该装置相当于轴流式血泵 ,但结构简单。装置的“转子—叶轮体”由动脉壁外的交变磁场提供动力 ,磁场源还可放置于体外发挥作用。动力性主动脉瓣比传统的轴流式血泵有很多潜在优点 ,如 :体积减小 ,解剖相容性更好 ;由于引入体内的异物量很少 ,生物相容性将大大提高 ;血流的持续冲刷将提高装置的抗感染能力 ;完全去除供能导线的穿入体内 ,大大提高病人的生活质量。我们先前对动力瓣的研究揭示其原理的正确性 ,但功率输出急需提高。我们对动力瓣的结构进行了改进 ,并采用了远距离磁驱动技术。在模拟循环回路中的测试结果表明动力特性有很大提高。在最大输出条件下 ,流量达到 5L/min ,所克服的后负荷压强为 70mmHg(1mmHg =0 .133KPa)。动力瓣可维持的最高压强差已达 131mmHg。磁驱动装置与动力瓣的距离可达 6 0mm ,显示实现体外磁驱动的可能性。此改进可大大简化植入部分的结构 ,进一步表明实现动力瓣设想的可行性。We have previously proposed and demonstrated the feasibility of a new concept of intraaortic axial flow blood pump,termed “Dynamic Aortic Valve(DAV)”.Implanted in the position of aortic valve,DAV can serve as either an assistant pump or a mechanical valve subjected to the power input.It has several merits over the traditional axial blood pumps:(1)better anatomic compatibility and biologic compatibility;(2)little foreign material is to be introduced into the corporeality;(3)better resistance to infection;(4)puncturing power line could be eliminated;(5)promoting the failing heart to recovery;(6)simpler structure and better durability.In our recent studies,the structure of DAV is further simplified and performance improved greatly.The structure of DAV is merely an impeller fixed to a magnetic rotor while held by a central shaft hanging from a rigid supporting cage.The rotor impeller can be driven by an alternative magnetic field derived from a remote magnet,implying that the magnetic source can even be arranged extracorporeally.The DAV can be driven by a rotational magnet placed at a distance of 60mm.At the state of maximal output of hydraulic power,the flow rate (FR)generated by DAV reaches 5L/min against an afterload of 70 mmHg(1mmHg=0.133KPa).The maximal pressure differential (PD) maintained by DAV is 131 mmHg.The results further revealed the feasibility of the concept of DAV.

关 键 词：左心辅助 旋转叶轮泵 人工心脏 瓣-泵 动力性主动脉瓣 

分 类 号：R318.1[医药卫生—生物医学工程]