胎儿宫内生长迟缓孕妇静脉血及其新生儿脐血一氧化氮水平测定的临床意义  

Changes of Maternal and Umbilical Serum Nitric Oxide in Patients with the Intrauterine Growth Retardation

作　　者：徐开红[1] 董旻岳[1] 周坚红[1] 石一复[1] 

机构地区：[1]浙江大学医学院附属妇产科医院产科,杭州310006

出　　处：《中华妇产科杂志》2000年第12期715-716,共2页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　探讨一氧化氮 (nitricoxide ,NO)水平变化与胎儿宫内生长迟缓 (IUGR)发病的关系。方法　采用硝酸根还原酶还原、格瑞显色法 ,测定 15例IUGR孕妇 (IUGR组 )、2 5例分娩正常体重儿的孕妇 (对照组 )静脉血及其新生儿脐血中NO的稳定代谢产物亚硝酸基 /硝酸基 (NO-2 /NO-3 )水平。结果　IUGR组患者血NO-2 /NO-3 水平为 (74 2 2± 2 8 99) μmol/L ,对照组孕妇为 (5 6 71± 2 2 81)μmol/L ;IUGR组新生儿脐血NO-2 /NO-3 水平为 (39 73± 2 4 6 5 ) μmol/L ,对照组新生儿脐血为 (2 1 49±6 6 9) μmol/L。与对照组比较 ,IUGR组患者血NO-2 /NO-3 水平显著升高 (P <0 0 5 ) ,其新生儿脐血NO-2 /NO-3 水平也显著升高 (P <0 0 0 1)。两组新生儿脐血中NO-2 /NO-3 水平均显著低于其孕母血中的水平 (P <0 0 5 )。结论　孕妇及其新生儿NO水平的变化 ,是IUGR继发性代偿反应的结果 ;NO代谢失调可能与IUGR的发病有关。Objective To determine whether the levels of maternal and umbilical serum nitric oxide (NO) were changed in cases of intrauterine growth retardation (IUGR). Methods Fifteen pregnant women with fetuses of IUGR (IUGR group) and 25 normal pregnant women in late trimester (normal control group) were studied. Maternal and fetal umbilical venous blood were collected from all the cases. Serum NO - 2/NO - 3, the end products of NO, were measured with the Griess reaction after reduction with nitrate reductase. Results Mean NO 2 -/NO 3 - values in maternal serum were (72.22±28.99) μmol/L in IUGR group and (56.71±22.81) μmol/L in the control. Umbilical serum NO 2 -/NO 3 - values were (39.73±24.65) μmol/L in IUGR group and (21.49±6.69)μmol/L in the control.Compared with the control,maternal as well as umbilical serum NO 2 -/NO 3 - in IUGR group were significantly higher ( P <0.05 and P <0.001,respectively).The total nitrite levels in fetal circulation were lower than in maternal circulation in both groups ( P <0.05). Conclusions [WT5”,6BZ]Changes of NO in the pregnant women and their fetuses were due to the result of secondary complementary response in the patients with IUGR.The metabolic disorder of nitric oxide in maternal and fetal circulation may play an important role in pathogenesis of IUGR.

关 键 词：胎儿宫内生长迟缓 一氧化氮 静脉血 脐血 

分 类 号：R714.5[医药卫生—妇产科学]