吡格列酮、二甲双胍联合预处理对多囊卵巢综合征不孕的疗效观察  

Efficacy of Pretreatment with Combined-use of Pioglitazone and Metformin in Patients with PCOS-related Infertility

作　　者：邹会玲[1] 戚亚兰 孙宇[1] 

机构地区：[1]南京鼓楼医院集团宿迁市人民医院,江苏省宿迁市223800

出　　处：《医学理论与实践》2014年第1期13-14,共2页The Journal of Medical Theory and Practice

摘　　要：目的:观察多囊卵巢综合征(PCOS)合并不孕患者采用吡格列酮及二甲双胍联合预处理的临床疗效。方法:将符合PCOS诊断的不孕患者86例采用吡格列酮及二甲双胍联合预处理,再用克罗米芬(CC)+人尿促性腺激素(HMG)促排卵方案治疗。比较用药前、后血清黄体生成素(LH)、LH/促卵泡素(FSH)、睾酮(T)、空腹胰岛素(FINS)的变化,以及周期排卵率和妊娠率。结果:治疗前、后血清LH、LH/FSH、T、FINS均有下降,且差异均具有统计学意义(P<0.05)。结论:吡格列酮及二甲双胍联合预处理治疗PCOS不孕,可有效地改善胰岛素抵抗,降低血清LH、LH/FSH、T水平,并且提高PCOS不孕患者的排卵率及妊娠率。Objective： To investigate the efficacy of pretrceatment with combined-use of pioglitazone and metformin in patients with polyeystic ovarian syndrome （PClDS）-related infertility. Methods： 86 patients with PCOS-related infertility treated with combined-use of pioglitazone and metformin pretreatmcnt and followed by elomiphene and human menopa- usal gonadotropin for induction of ovulation. Serum levels of LH, LH/FSH, T and fasting insulin （FINS） and the rates of induction of ovulation and pregnancy were examined before and after treatment. Results： In the therapy group, LH, LH/FSH, T, FINS was obviously decreased after treatment. And the difference was statistically significant（P〈0. 05）. Conclusion：Combined-use pretreatment with pioglitazone and metformin in PC~）S patients of infertility can reduce more efficacy the insulin resistance, decrease serum levels of LH, LH/FSH and T and improve the rate of induction of ovula- tion and pregnancy.

关 键 词：吡格列酮 二甲双胍 多囊卵巢综合征 不孕胰岛素抵抗 

分 类 号：R711[医药卫生—妇产科学]