均匀设计优选抗痴呆胶囊(复方)的提取工艺  

Optimization of Extraction Process for Anti-Dementia Capsules with Uniform Design

作　　者：蒋丽君[1] 夏新华[2] 

机构地区：[1]湖南中医学院附属第二医院,湖南长沙410005 [2]湖南中医学院药学分院,湖南长沙410007

出　　处：《中成药》2000年第11期758-760,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :以丹参酮ⅡA 的含量为指标 ,研究抗痴呆胶囊醇提工艺。方法 :采用均匀设计法对抗痴呆胶囊醇提工艺进行考察 ,用HPLC法测定丹参酮ⅡA 的含量。结果 :采用 95 %的乙醇 ,固液比例 1∶12 ,浸泡 2 4h ,回流时间 30min ,重复 2次所得到的丹参酮ⅡA 的含量高。结论 :此工艺对丹参酮ⅡA 的提取高 ,稳定性好 ,适合工业化生产。Objective: To study the alcohol extraction process for Anti Dementia Capsules in tanshinone Ⅱ A as a marker. Methods: The alcohol extraction process for anti Dementia Capsules was studied with the method of uniform design. The content of tanshinone Ⅱ A was determined by HPLC. Results: The content of tanshinone Ⅱ A was the highest when the following extraction condition was used: extracting with 95% alcohol (the proportion of solid to liquid was 1∶12), infusing medical materials for 24h and refluxing for 30min. The process was repeated twice. Conclusion: The content of tanshinone Ⅱ A is high and its stability is good when this extraction process is used. This extraction process is suitable for industrial production.

关 键 词：抗痴呆胶囊 丹参酮ⅡA 提取 均匀设计 

分 类 号：R284.2[医药卫生—中药学]