托盘根乙醇提取物对淋巴细胞转化及IL-2产生的影响  

The Effects of ERC on Spleen Lymphocyte Transformation and IL-2 Production

作　　者：徐颖[1] 杜钢军[1] 牟孝硕[1] 孙朋悦 张宝凤[1] 胡晓芳[2] 

机构地区：[1]沈阳药科大学药学系,沈阳110015 [2]沈阳军区总医院检验科,沈阳110015

出　　处：《沈阳药科大学学报》2000年第6期438-440,共3页Journal of Shenyang Pharmaceutical University

摘　　要：作者选用C57BL/6J小鼠、老龄小鼠和环磷酰胺 (CY)所致免疫功能低下小鼠模型 ,观察了托盘根乙醇提取物 (ERC)对正常小鼠、老龄小鼠和CY鼠淋巴细胞转化及IL 2生成的影响 .ERC40 0 μg/mL可促进正常小鼠的淋巴细胞转化功能 ;ERC 40 0、2 0 0、10 0 μg/mL对老龄小鼠的淋巴细胞转化有明显的促进作用 ;ERC 40 0、2 0 0 μg/mL对CY所致的免疫功能低下小鼠的淋巴细胞转化也有促进作用 .同时作者还观察到ERC 40 0 μg/mL能增加正常小鼠脾淋巴细胞IL 2的生成 ;ERC40 0、2 0 0、10 0 μg/mL对老龄小鼠脾淋巴细胞IL 2的生成均有促进作用 .The effects of ERC(extract of Rubus crataegifolius )on spleen lymphocyte transformation and IL-2 production of normal mice,aged mice and CY-treated mice were observed.The results indicated that ERC 400 μg/mL improved lymphocyte transformation of normal mice,that ERC 400,200,100 μg/mL increased the transformed rate of aged mice,and that ERC 400,200 μg/mL also improved lymphocyte transformation of CY-treated mice.Meanwhile,the results also indicated that ERC 400 μg/mL could enhance IL-2 production of normal mice,and that ERC 400,200,100 μg/mL could increased the IL-2 production of aged mice.

关 键 词：托盘根乙醇提取物 淋巴细胞转化 IL-2 小鼠 

分 类 号：R285.5[医药卫生—中药学]