益母草注射液与缩宫素对子宫缩复作用的随机对照研究  

Randomized controlled study of effects of leonurus heterophyllus injection and oxytocin on postpartum hemorrhage

作　　者：雷玲[1] 李力[1] 俞丽丽[1] 郑英如[1] 郭建新[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所妇产科,重庆400042

出　　处：《重庆医学》2014年第2期152-154,共3页Chongqing medicine

基　　金：国家"十五"科技攻关项目(项2004BA720A06-01)

摘　　要：摘要：目的研究益母草注射液与缩官素及二者联合使用对剖宫产和经阴道分娩产后出血的治疗效果。方法研究对象为因医学因素或社会因素需行剖宫产者60例，经阴道分娩者54例，将其用盲法随机分至3组：益母草组、缩宫素组、益母草＋缩官素组，各组按特定方式处理，记录术中及产后48h内出血量，记录第三产程时间，所得数据用单因素方差分析法进行统计分析。结果益母草组剖宫产组术中出血量为（1014．75±159．10）mL，益母草＋缩宫素组为（433．88±75．34）mL，缩宫素组为（562．30±102．00）mL，组间比较差异有统计学意义（F=67．48，P〈0．01）。posthocLSD检验显示，在P〈0．05水平下，LSD-109．58，提示两组间差异有统计学意义；经阴道分娩组，总出血量、产后2h及2～6h出血量3组间比较差异均无统计学意义，其余检测时段差异有统计学意义，其中益母草组与缩宫素组相比，24h后的出血量相对较少；剖宫产组3组间第三产程比较差异均无统计学意义。结论益母草用于阴道分娩后，可以达到与缩宫素类似的效果，在剖宫产时不建议单独使用。Objective To investigate the effects of leonurus heterophyllus injection and oxytocin and their combination applica- tion in treating postpartum hemorrhage. Methods Sixty cases of cesarean section due to the medical factors or the social factors and 54 cases of vaginal delivery were randomly divided into ：3 groups by the blind method, i. e. the leonurus heterophyllus injection group,the oxytocin group and the leonurus heterophyllus injection plus oxytocin group. Each group was treated by the specific mode. The amounts of intraoperative bleeding and at postpartum 48 h bleeding were recorded,and the time of the third stage of la- bor was recorded. One way Anova was used to analyze the obtained data. Results The intraoperative bleeding amounts were （1 014.75~ 159.10） mL in the leonurus heterophyllus injection group and the cesarean section group, （433.88--＋-_ 75.34） mL in the leonurus heterophyllus injection plus oxytocin group and（562.30 ~ 102.00） mL in the oxytocin group, the difference among the groups were statistically significant（F= 67.48, P〈0.01）. The post hoc LSD test showed that under P〈0.05, LSD= 109.58,indi- cating the significant diferences between the two groups;in the vaginal delivery group,no statistical dii[erence in the total bleeding amounts,postpartum 2 h and 2--6 h bleeding amounts had no statistical differences among 3 groups,but the other time periods of detection had dif{erence,in which,compared with the oxytocin group, postpartum 24 h bleeding amount in the leonurus heterophyl lus injection group was relatively less;in the cesarean section group, the third stage of labor had no statistical difference among 3 kinds of treatment group. Conclusion Using leonurus heterophyllus injection after vaginal delivery can reach the similar effect as oxytocin. However,Ieonurus heterophyllus injection is not recommended to be exclusively used in cesarean section.

关 键 词：益母草 催产素 剖宫产术 自然分娩 产后出血 

分 类 号：R714.461[医药卫生—妇产科学]