脱氢表雄酮硫酸盐对老年大鼠学习、记忆功能的促进作用  

The effect of dehydroepiandrosterone sulfate on learning and memory in the old rats

作　　者：孙宜萍[1] 毛敏伟[1] 陆懿[1] 严钱勤[1] 

机构地区：[1]上海市第六人民医院老年科,上海200233

出　　处：《中国神经科学杂志》2000年第4期333-335,共3页

摘　　要：探讨脱氢表雄酮硫酸盐 (DHEAS)对老年大鼠迷宫光亮分辨反应的学习能力和记忆保存的影响。将2月龄年轻雄性 SD大鼠 30只 ,2 2月龄老年雄性 SD大鼠 2 8只 ,分别随机分为对照组和实验组。实验组给予DHEAS 2 0 mg/kg,对照组给予等量 5%葡萄糖 ,均腹腔注射。然后分别作 Y迷宫光亮分辨反应的学习能力测试 ,1 2 d后以同样方法检查大鼠的记忆保存能力。结果提示 :1学习能力测试 ,2 2月龄老年大鼠的 Y迷宫光亮分辨学习达到标准的训练次数为实验组 (2 0 .8± 4.3)次 ,对照组 (34.8± 6.1 )次 ,两组间差别非常显著(P<0 .0 5) ;年轻大鼠实验组 (2 3.6± 2 .8)次 ,对照组 (2 0 .4± 4.1 )次 ,两组间差别无显著性。 2记忆保存测试 ,老年大鼠达到标准所需次数为实验组 (3.0± 1 .7)次 ,对照组 (1 4.2± 2 .1 )次 ,差别非常显著 (P<0 .0 1 ) ;年轻大鼠实验组 (2 .1± 0 .7)次 ,对照组 (1 0 .3± 2 .8)次 ,差别非常显著 (P<0 .0 1 ) ;老年大鼠实验组与年轻大鼠实验组的学习能力、记忆保存比较无显著差别 (P>0 .0 5)。To study the effect of dehydroepiandrosterone sulfate (DHEAS)on learning and memory in the old rat,both 30 young rats(2 month old) and 28 old rats (22 month old)were divided at random into the control groups and test groups respectively. The test groups were injected with DHEAS 20 mg/kg,the control groups were injected with 5% glucose solution instead.Then the learning ability of rats was measured by using Y maze brightness discrimination learning model.The memory was measured with the same method after 12 days.In Y maze brightness discrimination learning test,the trials to criterion in the old test group and control group were 20 8±4 8 and 34 8±6 1 respectively ( P <0 05),while in the young test group and control group were 23 6±2 8 and 20 4±4 1,respectively( P >0 05).In memory retention test,the trials to criterion in the old test group and control group were 3 0±1 7 and 14 2±2 1 respectively( P <0 01),and those in the young test group and control group were 2 1±0 7 and 10 3±2 8, respectively ( P <0 01).No significant difference was seen in the function of learning and memory retention between the old groups and young groups.Therefore,it is concluded that dehydroepiandrosterone sulfate may improve the abilities of learning and memory in the old rats.

关 键 词：脱氢表雄酮硫酸盐 Y迷宫光亮分辨 记忆保存 

分 类 号：R338[医药卫生—人体生理学]