杀菌剂肟菌酯的合成工艺  

Synthesis process of trifloxystrobin

作　　者：陈伟[1] 房晓敏[1] 杨莉[1] 雷天乾 徐元清[1] 丁涛[1] 

机构地区：[1]河南大学化学化工学院,精细化学与工程研究所,河南开封475004 [2]开封博凯生物化工有限公司,河南开封475000

出　　处：《化学研究》2014年第1期16-19,共4页Chemical Research

基　　金：河南省科技厅基础前沿项目(132300410238)

摘　　要：以邻甲基苯乙酸为起始原料,经过氧化、酯化、肟化及溴代反应,最后与间三氟甲基苯乙酮肟缩合制备了杀菌剂肟菌酯.每步的反应产物均通过1 H NMR确认,总收率为17%.本工艺路线采用廉价的起始原料降低了生产成本,反应条件温和且易于控制,各步收率较高,有进一步研究与应用价值.Trifloxystrobin was synthesized with a new method which adopted 2-methyl phenylacetate as the starting material through partial oxidation, esterification, oximation, bromization and condensation finally with 3＇-（trifluoromethyl） acetophenone oxime. The reaction products of each step were confirmed by 1H NMR. The total yield was about 17%. The process route uses inexpensive starting materials, and reaction conditions are mild and easy control with good yield of each step, which is worthy of further study.

关 键 词：邻甲基苯乙酸 杀菌剂 肟菌酯 合成 

分 类 号：TQ460.2[化学工程—制药化工]