苯丙氨酸锂催化醛和胺以及三甲基硅腈三组分的Strecker反应(英文)  

Three-component Strecker reaction of aldehyde,amine and trimethylsilyl cyanide catalyzed by phenylalanine lithium

作　　者：刘梦杰[1,2] 郭辉[2] 王幸伟 王心义[1] 邓冬生[1,2] 

机构地区：[1]河南理工大学资源环境学院,河南焦作454150 [2]洛阳师范学院化学化工学院,河南洛阳471022

出　　处：《化学研究》2014年第1期37-40,共4页Chemical Research

基　　金：National Natural Science Foundation of China(21272109)

摘　　要：以苯丙氨基酸锂为催化剂,成功催化了醛、胺和三甲基硅腈三组分的Strecker反应,并结合一系列氨基酸盐催化剂的筛选以及各种溶剂的选择优化了反应条件.结果表明,利用所述反应可以得到较高收率的α-氨基腈;该三组份的Strecker反应具有反应条件温和、反应收率较高、操作简便、无需繁琐的分离步骤、催化剂便宜且环境友好等优点.The three-component Strecker reaction of aldehyde, amine and trimethyl silyl cyanide was successfully carried out with L-phenylalanine lithium as the catalyst. The reaction conditions were optimized in relation to the screening of a series of amino acid salt catalysts and the selection of various solvents. Results indicate that the present reaction can be adopted to Obtain a-amino nitriles in good yields. Furthermore, the protocol has the advantages of mild reaction conditions, good yield, simple operation, easy separation, and inexpensive and environmentally benign catalyst.

关 键 词：苯丙氨基酸锂 醛 胺 三甲基硅腈 三组分Strecker反应 

分 类 号：O621[理学—有机化学]