来曲唑与克罗米芬对多囊卵巢综合征患者促排卵效果观察  

Observation of letrozole and colmiphene for ovulation induction in PCOS women

作　　者：褚志平[1] 戴雪[1] 陈沿东[1] 吴洁[2] 

机构地区：[1]南京医科大学第二附属医院,南京市210029 [2]南京医科大学第一附属医院生殖中心

出　　处：《护理实践与研究》2014年第1期41-43,共3页Nursing Practice and Research

摘　　要：目的：探讨来曲唑与克罗米芬治疗女性不孕多囊卵巢综合征（PCOS）的临床疗效.方法：选择我院2010年9月～2012年8月收治的50例诊断为PCOS的女性不孕症患者,随机分为来曲唑组和克罗米芬组各25例,并进行排卵期护理宣教.结果：来曲唑组患者共完成26个周期的治疗,克罗米芬组患者共完成25个周期的治疗.两组患者卵泡成熟天数、子宫内膜厚度、优势卵泡数、成熟卵泡数、妊娠率和卵泡发育率差异均无统计学意义（P＞0.05）,但来曲唑组的排卵率显著高于克罗米芬组（P＜0.05）.来曲唑组患者未出现异位妊娠和卵巢过度刺激综合征,克罗米芬组有1例发生卵巢过度刺激综合征.结论：来曲唑在治疗PCOS引起的女性不孕症中,可显著提高患者的排卵率.Objective：To observe the clinical efficacy of letrozole and elomiphene citrate （CC） for ovarian stimulation in polyeystic ovarian syndrome （ P- COS） women. Methods： 50 cases diagnosed in our hospital from September 2010 to August 2012 for the PCOS of female infertility patients, randomly divid- ed into letrozole group and clomiphene citrate group with 25 cases in each group, they all received nursing education in the period of ovulation. Results： 25 patients received 26 rounds letrozole treatment and the others received 25 rounds CC treatment. There was no statistical significance in ovarian follicles ma- ture days, eudometrial thickness, advantage follicle number, mature follicle number, pregnancy rate and ovarian follicles development rate differences be- tween two groups （ P 〉 0.05 ）. However, ovulation rate in letrozole group was significantly higher than CC group （ P 〈 0.05 ）. There was no eetopic pregnan- cy and ovarian hyper stimulation syndrome （OHSS） cases in letrozole group but one OHSS case in CC group. Conclusion： Letrozole could improve ovulation- rateevidently agent in PCOS women.

关 键 词：来曲唑 克罗米芬 促排卵 多囊卵巢综合征 不孕症 

分 类 号：R47[医药卫生—护理学]