呼吸道合胞病毒与TLR3、TLR4的关系及其中医药研究进展  

Relationship between RSV and TLR3, TLR4 and Chinese medicine research progress on RSV

作　　者：李涛[1] 戴启刚[1] 汪受传[1] 

机构地区：[1]南京中医药大学儿科研究所,南京210029

出　　处：《中华中医药杂志》2014年第1期211-213,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81072840);高等学校博士点专项科研基金(No.20103237110003)~~

摘　　要：文章结合免疫学、细胞分子生物学及中医学相关理论和方法,以Toll样受体3(TLR3)、Toll样受体4(TLR4)的化学生物学特性为基点,结合国内外最新研究进展,从TLR3、TLR4的信号通路、此信号通路与呼吸道合胞病毒(RSV)感染性肺炎的关系及RSV对TLR3、TLR4信号通路表达的影响几个方面,阐述了TLR3、TLR4与RSV的病理生理联系,并在此基础上结合中医药在呼吸道合胞病毒性肺炎防治中的最新研究成果,探讨了运用中药提取物、中药复方及中成药治疗RSV型肺炎的优势,以期在分子、蛋白水平为中医药治疗RSV型肺炎提供必要的理论依据。Combined with relevant theories and methods of immunology, cell and molecular biology and traditional Chinese medicine, putting the chemical biology characteristics of TLR3, TLR4 as basis, this paper discussed the physiopathologic relationship between TLR3, TLR4 and respiratory syncytial virus （RSV） from the following several aspects： the signaling pathways of TLR3, TLR4, the relation between these signaling pathways and respiratory syncytial virus （RSV） infectious pneumonia, and the influence of RSV on TLR3, TLR4 signaling pathways expression. On the basis of the latest research results in prevention and cure of RSV pneumonia, this paper discussed advantages of using traditional Chinese medicine extract, Chinese medicine compound and proprietary Chinese medicine to treat RSV pneumonia, in order to provide necessary theoretical basis for traditional Chinese medicine to RSV pneumonia in the molecules and protein level.

关 键 词：呼吸道合胞病毒 TOLL样受体3 TOLL样受体4 中医药 

分 类 号：R725.6[医药卫生—儿科]