抵抗素rs1862513与广东地区2型糖尿病的相关性研究  

Research on correlation between resistin rs1862513 with type 2 diabetes mellitus in Guangdong area

作　　者：徐英 王李莉[2] 周强[3] 邓聪[3] 陈波[3] 黄海樱[3] 林桢[3] 杨静[3] 夏少梅[3] 

机构地区：[1]西藏林芝地区人民医院检验科,860000 [2]南方医科大学检验系,2008级广州510630 [3]广州医科大学附属第二医院检验科,广州510260

出　　处：《检验医学与临床》2014年第2期147-149,共3页Laboratory Medicine and Clinic

基　　金：广东省科技计划项目(2012B061700044);广东省医学科研基金资助项目(A2012256)

摘　　要：目的探讨抵抗素（rs）1862513与广东地区2型糖尿病的相关性。方法收集2010年i0月至20n年10月广州医学院第二附属医院收治的新诊断为2型糖尿病的患者182例为治疗组，选择同期健康体检者191例为健康对照组，比较两组血清rsl862513位点C／G基因型的分布频率及logistic回归分析结果。结果rsl862513位点基因型频率已达到遗传平衡，具有群体代表性。其中．χ2=4．645，P=0．098，rsl862513位点C／G基因型的分布频率差异无统计学意义（P〉0．05）；GG纯舍子患病率是CC纯合子患病率的1．375倍（OR=1．375，95％CI：0．575～3．285），基因型间危险度差异无统计学意义（P〉0．05）。结论rsl862513基因型与广东地区2型糖尿病并无相关性。Objective To explore the relationship between resistin rs1862513 with type 2 diabetes mellitus （T2DM） in Guangdong area. Methods 182 cases of newly diagnosed T2DM in the Second Affiliated Hospital of Guangzhou Medical College from October 2010 to October 2011 were collected as the treatment group and contempo- raneous 191 subjects with healthy physical examination as the control group. The distribution frequency of rs1862513 locus C/G genotype and the logistic regression analysis results were compared. Results The genotype frequency of rs1862513 locus reached the genetic equilibrium with the group representative. Among them, χ2 = 4. 645, P= 0. 098, the difference of distribution frequency of rs1862513 locus C/G genotype had no statistical significance（P〉0.05）; the morbidity rate of GG homozygote was 1. 375 times of the mobidity rate of CC homozygote（OR= 1. 375,95 % CI： 0. 575-3. 285）. The difference of the risk degrees among genotypes had no statistical significance（P：〉0.05）. Conclu- sion rs1862513 genotype has no correlation with T2DM in Guangdong area.

关 键 词：2型糖尿病 抵抗素 胰岛素抵抗 单核苷酸多态性 

分 类 号：R587.1[医药卫生—内分泌]