术前放疗和化疗联合手术治疗老年中晚期食管癌的疗效观察  

Observation on effect of surgery combined with preoperative chemotherapy and radiotherapy for treating elderly advanced esophageal cancer

作　　者：陈勇吉[1] 李志强[1] 江向明[1] 

机构地区：[1]四川省崇州市人民医院胸外科,611230

出　　处：《检验医学与临床》2014年第2期188-190,共3页Laboratory Medicine and Clinic

摘　　要：目的分析术前放、化疗联合手术治疗老年中晚期食管癌的临床疗效。方法将60例老年食管癌患者随机分为术前放、化疗联合手术治疗组（联合治疗组）和单纯手术组，每组各30例。联合治疗组术前予以辅助放、化疗，放、化疗结束3～5周后行手术切除治疗；单纯手术组仅实施手术治疗。结果联合治疗组总有效率为76．67％，明显优于单纯手术组的30．00％（P〈0．05），且联合治疗组患者术后骨髓抑制、恶心呕吐及放射性食管炎发生率均低于单纯手术组（P〈0．05）。患者总随访率为96．67％，随访结果显示联合治疗组总复发率低于单纯手术组，且除1年局部控制率两组间差异无统计学意义（P〉0．05）外，联合治疗组的肿瘤局部控制率、生存率均明显优于单纯手术组（P〈0．05）。结论术前辅助放、化疗能提高老年中、晚期食管癌手术疗效，提高肿瘤局部控制率和生存率，减少肿瘤复发和转移。Objective To investigate the clinical curative effect of surgery combined with preoperative chemo- therapy and radiotherapy for treating elderly advanced esophageal cancer. Methods A total of 60 elderly patients with esophageal cancer were randomly divided into the combined therapy group and the simple surgery group, with 30 cases in each group. The combined therapy group was giren the preoperative assisted radiochemotherapy,and per- formed the operative resection in 3--5 weeks after radiochemotherapy, while the simple surgery group was treated by surgery alone. Results The overall effective rate in the combined therapy group was 76.67%, which was signifi- cantly higher than 30.00% the simple surgery group（P〈0.05）, and the occurrence rates of bone marrow suppres- sion, nausea, vomiting and esophagitis in the combined therapy group were lower than those in the simple surgery group （P〈0.05）. The total follow-up rate was 96.67%, and in the combined therapy group, the total recurrence rate, local tumor control rate and survival rate were significantly superior to those in the simple occurrence surgery group （P〈0.05）. Conclusion The assisted preoperatire chemotherapy and radiotherapy could improve the curative effect of surgery for elderly advanced esophageal cancer, improve the local tumor control rate and the survival rate, and reduce tumor recurrence and tumor metastasis.

关 键 词：食管癌 术前放化疗 外科手术 老年 

分 类 号：R697.32[医药卫生—泌尿科学]