速激肽及其受体在哮喘中的研究进展  

Progresses of tachykinins and its receptors in asthma

作　　者：刘立云(综述)[1] 郭锡斌[1] 韩晓华[1] 尚云晓(审校)[1] 

机构地区：[1]中国医科大学附属盛京医院儿科,沈阳110004

出　　处：《国际儿科学杂志》2014年第1期25-28,共4页International Journal of Pediatrics

摘　　要：速激肽是在气道的许多功能中发挥作用的重要介质.速激肽P物质及神经激肽A存在于人类呼吸道中,当受到一系列的刺激时,它们能从呼吸道中释放并分别与相应的受体结合,引起气道收缩、血浆外渗、黏膜分泌,并能吸引和激活免疫细胞和炎症细胞,在哮喘的发生和发展中起着重要的作用.然而,速激肽受体拮抗剂在临床上的应用不甚理想,这与临床前试验中速激肽及其受体的作用相差较大.关于速激肽在哮喘方面的作用仍然需要深入的基础研究及大规模的临床试验.Tachykinins are potent mediators of many functions in the airways. The tachykinins substance P and neurokinin A,presenting in human airways, can be recovered from the airways after a series of stimuli. They interact in the airways with tachykinin Neurokininl ,Neuroldnird and Neurokinin3 receptors to cause bron- choconstdction, plasma extravasation, mucus secretion and to attract and activate immune cells and inflammation cells. They play a important role in the pathophysiology of asthma. However, the application of tachykinin recep- tor antagonists in clinic has been rather slow and somehow disappointing and needs to be further studied.

关 键 词：速激肽 P物质 神经激肽A 哮喘 

分 类 号：R392.11[医药卫生—免疫学]