抗角蛋白抗体和抗环瓜氨酸肽抗体检测在类风湿关节炎中的临床意义  

The clinical significance of the detection of AKA and anti-CCP antibodies in rheumatoid arthritis

作　　者：陶月[1] 戴蕾[1] 宋景秋[1] 

机构地区：[1]南京大学医学院附属南京市鼓楼医院检验科,江苏南京210008

出　　处：《国际检验医学杂志》2014年第2期168-169,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨抗角蛋白抗体(anti-keratin antibodies,AKA)和抗环瓜氨酸肽(anti-cyclic citrullinated peptide,CCP)抗体检测对类风湿关节炎(rheumatoid arthritis,RA)诊断的指导意义。方法回顾性分析2012年7月至2013年5月间在该院就诊的1 209例患者的血清AKA和抗CCP抗体的检测结果,其中类风湿关节炎患者241例,其他患者968例,所有血清以间接免疫荧光法检测AKA,酶联免疫法检测抗CCP抗体。结果在类风湿关节炎患者中,AKA和抗CCP抗体的阳性率分别为49.79%和68.46%,在非类风湿关节炎的患者中的阳性率分别为2.69%和2.79%,差异均有统计学意义(P<0.01);AKA的特异性为97.31%,抗CCP抗体的特异性为97.21%。结论 AKA和抗CCP抗体的检测具有较高的特异性,对类风湿关节炎的辅助诊断具有重要意义。Objective To investigate the significance of anti keratin antibodies （AKA） and anti-cyclic citrullinated peptide （CCP） antibodies for the clinical diagnosis of rheumatoid arthritis（RA）. Methods Retrospective analysis of 1 209 cases from July 2012 to May 2013 in our hospital received serum AKA and CCP tests was done,of which 241 cases with rheumatoid arthritis and 9.q,q cases with other patients. All patients serum AKA was detected by indirect immunofluorescence assay, and enzyme-linked im- munosorbent was used to assay anti-CCP. Results In patients with rheumatoid arthritis, AKA and CCP positive rates were 49.79 % and 68.46 % ,respectively,and in the non-RA patients, the positive rates were 2.69% and 2.79 %, respectively. The RA and non RA groups were compared,and the difference was statistically significant. AKA specificity was 97. 31% ,and anti CCP specificity was 97.21%. Conclusion AKA and CCP detection have high specificity,which are useful markers for diagnosing and screening of rheu matoid arthritis.

关 键 词：角蛋白质类 抗环瓜氨酸肽抗体 关节炎 类风湿 

分 类 号：R593.22[医药卫生—内科学]