凝血因子Ⅴ、Ⅷ和组织因子与2型糖尿病合并冠心病的关系  

Relationship of coagulation factor Ⅴ and Ⅷ and tissue factor with type 2 diabetes mellitus combined with coronary heart disease

作　　者：王晓[1] 朱均权 

机构地区：[1]嵊州市人民医院检验科,浙江嵊州312400

出　　处：《检验医学》2014年第1期34-37,共4页Laboratory Medicine

摘　　要：目的探讨凝血因子Ⅴ活性(FⅤ:C)、凝血因子Ⅷ活性(FⅧ:C)和组织因子(TF)在2型糖尿病(T2DM)合并冠心病(HD)诊断中的应用价值。方法测定85例T2DM合并CHD患者[T2DM合并CHD组,根据CHD不同类型再分为T2DM合并急性心肌梗死(AMI)组(19例)、T2DM合并陈旧性心肌梗死(OMI)组(23例)、T2DM合并不稳定型心绞痛(UAP)组(25例)、T2DM合并稳定型心绞痛(SAP)组(18例)]、29例无合并症的单纯T2DM患者(单纯T2DM组)和24名健康对照者(正常对照组)FⅤ:C、FⅧ:C、血浆TF和血管性血友病因子(VWF)活性及血小板聚集率(PAR),并分析FⅤ:C、FⅧ:C、TF与VWF、PAR的相关性。结果 T2DM合并CHD组和单纯T2DM组FⅤ:C、FⅧ:C和TF水平均明显高于正常对照组(P<0.001),且T2DM合并CHD组明显高于单纯T2DM组(P<0.01)。T2DM合并CHD组中,T2DM合并AMI组和T2DM合并UAP组FⅤ:C、FⅧ:C和TF水平均明显高于单纯T2DM组(P<0.001),且T2DM合并AMI组明显高于T2DM合并UAP组(P<0.01);T2DM合并OMI组和T2DM合并SAP组TF水平明显高于单纯T2DM组(P<0.01),但FⅤ:C和FⅧ:C水平3组之间差异无统计学意义(P>0.05)。FⅤ:C、FⅧ:C、TF与VWF、PAR均呈明显正相关(P<0.01)。结论FⅤ:C和FⅧ:C及TF水平可作为T2DM患者并发CHD的诊断指标。TF对判断T2DM合并CHD患者病情的进展有重要价值。Objective To investigate the application significance of coagulation factor V and Ⅷ activities （FV ：C and Ⅷ ： C ） and tissue factor （TF） in diagnosis of type 2 diabetes mellitus （ T2 DM ） combined with coronary heart disease （CHD）. Methods FV ：C, FVIU：C, TF, von Willibrand factor（VWF） activity and platelet aggregation rate（PAR） were measured in 85 patients with T2DM combined with CHD [ T2DM with CHD group, including T2DM with acute myocardial infarction （AMI） group （19 cases）, T2DM with old myocardial infarction （OMI） group （23 cases）, T2DM with unstable angina pectoris （gAP） group （25 cases） and T2DM with stable angina pectoris（SAP） group （18 cases） ], 29 T2DM patients without complication （single T2DM group） and 24 healthy controls （control group）. The correlation between F V ：C, FⅧ：C and TF with VWF and PAR was analyzed. Results The levels of F V ：C, FⅧ：C and TF in T2DM with CHD group and single T2DM group were remarkably higher than those in control group （P 〈 0. 001 ）, and those in T2DM with CHD group were higher than those in single T2DM group（P 〈0.01 ）. In T2DM with AMI group and T2DM with UAP group, the levels of FV ：C,FⅧ：C and TF were markedly higher than those in single T2DM group（ P 〈 0. 001 ）, and those in T2DM with AMI group were higher than those in T2DM with UAP group （P 〈 0.01 ）. In T2DM with OMI group and T2DM with SAP group, the TF levels were significantly higher than those in single T2DM group（P 〈 0.01 ） , but there was no statistical significance among the 3 groups for F V ：C and FⅧ ：C levels（ P 〉 0.05 ）. There was a significantly positive correlation of F V ： C, FⅧ ： C and TF levels with VWF and PAR levels （ P 〈 0.01）. Conclusions FV：C, FⅧ：C and TF can be as the indicators for T2DM with CHD. TF is useful for the evaluation of disease development in patients with T2DM with CHD.

关 键 词：凝血因子V 凝血因子Ⅷ 组织因子 2型糖尿病 合冠心病 

分 类 号：R446.11[医药卫生—诊断学]