血清瘦素水平与产后甲状腺炎相关性的病例对照研究  

Association of serum leptin level with postpartum thyroiditis： A case control study

作　　者：郭慧玲[1] 李晨阳[2] 李玉姝[1] 桑淼[3] 单忠艳[1] 滕卫平[1] 关海霞[1] 

机构地区：[1]中国医科大学附属第一医院内分泌科,内分泌研究所.内分泌疾病重点实验室,沈阳110001 [2]沈阳市妇婴医院妇产科 [3]沈阳市第一人民医院内分泌科

出　　处：《中华内分泌代谢杂志》2014年第1期31-34,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金项目（81170731）

摘　　要：目的研究产后1年内血清瘦素水平的变化与产后甲状腺炎（PPT）发生的关系。方法以57例PPT患者（临床PPT34例，亚临床PPT23例）为病例组，37名健康产后女性为对照组。收集其产后3d和3、6、12个月的血清标本，采用放射免疫分析法测定瘦素水平。结果与对照组相比，病例组在产后1年内保持较高水平的瘦素和瘦素／体重指数（LEP／BMI）比值，差异具有统计学意义（P〈0．05或P〈0．01）。临床PPT患者和亚临床PPT患者相比，产后1年内各时间点的瘦素和LEP／BMI比值差异无统计学意义。病例组瘦素和LEP／BMI比值与TSH呈负相关，与FT3和FT4呈正相关。结论产后1年内持续较高水平的瘦素可能与PPT的发生有关，需要进一步的研究来阐明瘦素在PPT发生中的作用。Objective To investigate the association of serum leptin （LEP） levels during the first postpartum year with the occurrence of postpartum thyroiditis （PPT）. Methods Fifty-seven PPT patients consisted of 34 with overt PPT and 23 subclinical PPT. 37 healthy postpartum women were used as controls. Serum samples were obtained at 4 postpartum date points, i. e. 3-days and 3, 6, 12-months postpartum. LEP level was determined by radioimmunoassay. Results Compared with control women, PPT patients were maintaining significantly higher levels of LEP and LEP/body mass index （BMI） ratio during the first postpartum year. There was no significant difference in serum LEP level or LEP/BMI ratio between overt PPT and subclinical PPT groups. In PPT patients, LEP and LEP/BMI ratio were negatively correlated with serum TSH, and positively correlated with serum FT4 and FT3. Conclusion Sustained high levels of serum LEP after delivery may favor the occurrence of PPT. Further studies are needed to clarify the specific role played by LEP in PPT.

关 键 词：瘦素 产后甲状腺炎 自身免疫性甲状腺疾病 

分 类 号：R714.6[医药卫生—妇产科学]