穿虎痛风合剂治疗急性痛风性关节炎的临床研究  

A clinical study of Chuanhu anti-gout mixture in the treatment of acute gouty arthritis

作　　者：余霄龙[1] 李杨[1] 李恩泽[1] 李长贵[1] 王颜刚[1] 

机构地区：[1]青岛大学医学院附属医院内分泌科,266003

出　　处：《中华内分泌代谢杂志》2014年第1期49-51,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：采用随机、双盲双模拟、平行对照的非劣效试验设计方法，选取急性痛风性关节炎患者144例分为中药组（72例，穿虎痛风合剂）和秋水仙碱组（72例），治疗10d。结果显示，中药组和秋水仙碱组总有效率分别为93．02％和95．35％，差异无统计学意义，3个月后总复发率分别为12．50％和13．89％（P〈0．05）。不良反应发生率秋水仙碱组明显高于中药组（34．72％对2．78％，P〈0．01）。血尿酸、谷丙转氨酶、谷草转氨酶、肌酐治疗前后差值中药组均高于秋水仙碱组（P〈0．05或19〈0．01）。穿虎痛风合剂治疗急性痛风性关节炎的临床疗效与秋水仙碱相当。且安全性高。In this double-blind, double-dummy, non-inferiority study, 144 eases of newly diagnosed acute gouty arthritis were reassigned to Chuanhu anti-gout mixture group （ CH, n = 72 ） and colchicine group （ Col, n = 72）. After treatment for 10 days, the total efficiency rates of CH and Col groups were 93.02% and 95.35% , respectively, showing no difference between two groups. Three months later, the overall recurrence rates in CH and Col groups were 12.50% and 13.89% respectively （ P〈0.05 ）. The incidence of adverse reactions in colchicine group was significantly higher than CH group （34. 72% vs 2. 78%, P 〈 0. 01 ）. Blood uric acid, alanine aminotransferase, aspartate aminotransferase, and creatinine in CH group were decreased significantly compared with Col group （ P〈0.05 or P〈0.01 ）. The results suggest that the clinical efficacy of Chuanhu anti-gout mixture in the treatment of acute gouty arthritis was not inferior to colchicine, but with higher safety.

关 键 词：痛风 关节炎 中药 非劣效检验 

分 类 号：R589.7[医药卫生—内分泌]