2008-2012年河北某医院肺炎克雷伯菌的科室分布及耐药性的调查分析  

Survey on Klebsiella pneumoniae distribution during 2008-2012 in a hospital of Hebei and its drug resistance

作　　者：张梅[1] 杜红丽[1] 刘娜[1] 乔艳梅[1] 

机构地区：[1]衡水哈励逊国际和平医院检验科,河北衡水053000

出　　处：《现代预防医学》2014年第3期561-563,共3页Modern Preventive Medicine

摘　　要：目的了解五年内本医院临床分离的肺炎克雷伯菌的耐药现状,为临床预防控制和治疗肺炎克雷伯菌感染提供依据。方法收集2008-2012年从临床住院病人分离的肺炎克雷伯菌的药敏数据,并对其科室分布、标本类型、耐药状况进行回顾性分析。结果肺炎克雷伯菌主要来源于痰,主要分布在呼吸内科和ICU病区,耐药率最高的前5位抗菌药物为:氨苄西林、哌拉西林、头孢唑林、氨曲南、头孢呋辛,但对头孢哌酮/舒巴坦、亚安培南、美罗培南仍保持高度敏感,产ESBLs的肺炎克雷伯菌对抗菌药物的耐药性显著高于非产ESBLs菌。结论肺炎克雷伯菌耐药无明显增长趋势,应加强耐药监测,根据药敏结果合理选用抗菌药物,减少和减缓多重耐药菌株的产生。Objective To investigate drug resistance status of Klebsiella pneumoniae within five years in our hospital, and to provide references for control and therapy of Klebsiella pneumoniae infection. Methods Collected susceptibility data about Klebsiella pneumoniae from the inpatients in 2008-2012, and analyzed distribution of its departments, specimen type, drug resistance retro- spectively. Results Klebsiella pneumoniae from sputum, mainly distributed in respiratory medicine and ICU ward, the five antimi- crobial agents with highest resistance rate were ampicillin, piperacillin, cefazolin, aztreonam, cefuroxime, Klebsiella pneumouiae re- mained highly sensitive to cefoperazone / sulbactam, imipenem, meropenem, antimicrobial resistance of Klebsiella pneumoniae with ESBLs was significantly higher than that of non-ESBLs bacteria. Conclusion The drug resistance of Klebsiella pneumoniae has no significant growth trend, it should strengthen drug monitoring and rational use of antimicrobial drugs to reduce and slow down the generation of multiple-drug-resistant strains based on susceptibility results.

关 键 词：肺炎克雷伯菌 耐药性 抗菌药物 

分 类 号：R372[医药卫生—病原生物学]