Argonaute蛋白的结构与功能  

Structure and Biological Function of Argonautes

作　　者：苏雪婷[1] 李洁[1] 邵宁生[1] 

机构地区：[1]军事医学科学院基础医学研究所,北京市100850

出　　处：《医学分子生物学杂志》2014年第1期37-42,共6页Journal of Medical Molecular Biology

基　　金：国家重点基础研究发展计划（973计划）（№2011CB811300,2010CB912801）,国家自然科学基金（No.31100569,30971630,31370794）

摘　　要：Argonaute蛋白是RNA介导的转录后基因调控的关键蛋白。它为非编码小RNA提供锚位点，达到降解靶基因或者抑制翻译的目的。Argonaute蛋白广泛存在于真核生物中，在进化上高度保守。有关Argonaute蛋白的最新研究进展主要集中在人源AGO蛋白的晶体结构解析以及在此基础上对于非编码小RNA转录后调控机制的进一步理解；翻译后修饰对Argonaute蛋白功能的调控及Argonaute蛋白的新功能，譬如Argonaute蛋白在基因转录和DNA损伤修复过程中所发挥的作用。文章主要就哺乳动物Argonaute蛋白的结构与功能研究最新进展做一综述。Argonaute （AGO） protein is a key protein in RNA-mediated post-transcriptional gene regulation. It provides anchor sites for non-coding small RNA to degrade target genes or repress translation. AGO protein is highly conserved, and it family members are almost found in all eukaryotes. Recent research achievements on AGO protein mainly focused on the crystal structure of human AGO, based on which, how to further understand the regulation mechanism of post-transcription of non-coding small RNA, the regulation of AGO protein function by post-translational modification and novel biological effects of AGO in such as gene regulation and DNA repair. In this study, we reviewed the advances in the structure and functions of mammal AGO protein.

关 键 词：Argonaute蛋白 基因沉默 转录后调控 翻译后修饰 

分 类 号：Q74[生物学—分子生物学]