广西汉族婴幼儿皮肤血管瘤与HLA-DRB1等位基因的相关性研究  

Correlation between HLA-DRB1 Alleles and Infantile Cutaneous Hemangioma in Guangxi Han Population

作　　者：韦妮波[1] 陈深[2] 严煜林[1] 

机构地区：[1]广西医科大学第一附属医院皮肤性病科,广西南宁530021 [2]广西医科大学第六附属医院口腔科,广西玉林537000

出　　处：《皮肤性病诊疗学杂志》2013年第6期383-386,共4页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：广西自然科学基金资助项目(编号:2010GXNSFA013169)

摘　　要：目的:探讨HLA-DRB1等位基因多态性与广西汉族婴幼儿皮肤血管瘤的遗传相关性。方法:将广西汉族88例婴幼儿皮肤血管瘤患者(病例组)和105例正常汉族婴幼儿(对照组)作为研究对象。采用聚合酶链反应-序列特异性引物分型技术对两组HLA-DRB1等位基因进行分型,SPSS软件进行统计分析。结果:病例组HLA-DRB1*16等位基因频率为28.98%,明显高于对照组的14.76%(RR=3.29,P<0.05);病例组HLA-DRB1*1401等位基因频率为6.82%,明显低于对照组的16.67%(RR=0.32,P<0.05)。结论:HLA-DRB1*16可能为广西汉族婴幼儿皮肤血管瘤的易感基因。而HLADRB1*1401可能为其保护基因。Objective：To explore the genetic correlation between HLA-DRBI allele polymor- phisms and infantile cutaneous hemangioma in Guangxi Han population. Methods： 88 patients with infantile cutaneous hemangioma （study group） and 105 normal individuals （control group） were selected in Guangxi Han population as study subjects. HLA-DRB1 alleles in two groups were typed by polymerase chain reaction -sequence specific primers （PCR -SSP）. SPSS software was used for statistical analysis. Results：The frequency of HLA-DRB1 ＊ 16 allele in the study group was significantly higher than that in the control group （ 28.98% vs 14.76%, RR = 3.29, P 〈 0. 05）. Whereas the frequency of HLA-DRB1 ＊ 1401 allele in study group was significantly lower than that in control group （6. 82% vs 16. 67%, RR=0.32, P 〈 0. 05 ）. Conclusion： In Guangxi Han population, HLA-DRB1 ＊ 16 may be the predisposing gene of infantile cutaneous hemangio- ma, whileas HLA-DRB1 ＊ 1401 may be the protective gene.

关 键 词：血管瘤 婴幼儿 HLA-DRB1 

分 类 号：R739.5[医药卫生—肿瘤]