高血压与细胞氧化损伤  

Hypertension and cellular oxidative stress

作　　者：柳虎军 王晓辉[1] 刘生熙[1] 

机构地区：[1]中国人民解放军96531部队卫生防疫所

出　　处：《河南预防医学杂志》2014年第1期106-107,110,共3页Henan Journal of Preventive Medicine

摘　　要：高血压是心血管病中发病率最高及致死率亦最高的疾病,大量研究表明,氧化损伤可导致高血压大鼠肾脏损伤、血管内皮功能障碍、平滑肌细胞增殖、心肌纤维化等。而导致这些氧化损伤的活性氧主要是由细胞内NADPH氧化酶产生。通过抗氧化治疗可缓解由氧化损伤引起的血压升高。本文基于近期研究对细胞氧化损伤在高血压疾病中的作用做一小结。Hypertension is of the highest incidence and lethality in cardiovascular diseases. Oxidative stress is closely involved in hypertension induced renal injury, vassel endothelial dysfunction, smooth muscle proliferation and myocardial fibrosis. NADPH oxidase is the major cite producing reactive oxygen species. Antioxidative stresss is one of the effective approaches preventing pathogenesis of hypertension. We summarize the recent findings on cellular oxidative stress and hypertension in the review.

关 键 词：高血压 细胞氧化损伤 活性氧 

分 类 号：R544.1[医药卫生—心血管疾病]