老年高血压病患者颈动脉粥样硬化程度与血25-羟维生素D水平的相关性  

The Correlation Between Carotid Atherosclerosis of Elderly Hypertensive Patients and Serum 25-Hydroxyvitamin D Levels

作　　者：朱瑶[1] 费锦萍[1] 

机构地区：[1]浙江省宁波市第二医院老年医学科,浙江省宁波市315010

出　　处：《中国动脉硬化杂志》2013年第12期1139-1141,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨老年高血压病患者颈动脉粥样硬化程度与血25-羟维生素D[25(OH)D]水平的相关性。方法对2012年5月至12月间在宁波市第二医院就诊的老年高血压病患者经超声检测颈动脉内膜中膜厚度(IMT),根据颈动脉IMT将患者分为颈动脉正常组(60例,对照组)、颈动脉内膜增厚组(60例)和颈动脉斑块组(60例)。采用ELISA法测定三组患者血清25(OH)D水平,分析25(OH)D水平与颈动脉IMT的关系。结果颈动脉斑块组与颈动脉内膜增厚组血25(OH)D水平均低于颈动脉正常组(P<0.05),颈动脉斑块组血25(OH)D水平低于颈动脉内膜增厚组(P<0.05),差异均有统计学意义。结论低血25(OH)D水平的老年高血压病患者具有颈动脉粥样硬化程度加重的危险,血25(OH)D水平测定有助于预测颈动脉粥样硬化程度。Aim To investigate the correlation between carotid atherosclerosis and serum 25-hydroxyvitamin D （25（OH）D） levels of elderly hypertensive patients. Methods Carotid intima-media thickness（IMT） were detected by ultrasound in the elderly hypertensive patients from Ningbo No.2 hospital from May 2012 to December 2012. According carotid carotid IMT, 180 cases of elderly patients with hypertension were divided into normal carotid artery group （60 cases, control group）, carotid intimal thickening group （60 cases）, carotid plaque group （60 cases）. Serum 25（OH）D levels were measured by ELISA in three groups, and the relationship between carotid IMT and serum 25（OH）D levels was analysed. Results Serum 25（OH）D levels were lower in carotid artery plaque group and carotid intimal thickening group than in normal carotid artery group（P〈0.05）, and it was lower in carotid artery plaque group than in carotid intimal thickening group（P〈0.05）, and the differences were statistically significant. Conclusion Low serum 25（OH）D levels in elderly hypertensive patients increased risk of carotid atherosclerosis, the mesurement of serum 25（OH）D levels help predicting the degree of carotid atherosclerosis.

关 键 词：高血压病 颈动脉粥样硬化 25-羟维生素D 老年患者 

分 类 号：R5[医药卫生—内科学]