PM2.5对肺泡巨噬细胞功能影响的研究进展  

Effects of PM2.5 on alveolar macrophage functions: a review of recent studies

作　　者：熊琪[1] 茹琴[1] 陈琳[1] 陶晓南[2] 李超英[1] 

机构地区：[1]江汉大学武汉生物医学研究院,湖北武汉430056 [2]华中科技大学同济医学院附属协和医院呼吸科

出　　处：《环境与健康杂志》2013年第12期1128-1130,共3页Journal of Environment and Health

摘　　要：近年来我国大气PM2.5污染形势日趋严峻,已受到广泛关注。肺泡巨噬细胞是肺部和气道内抵御外来微生物的第一道防线,因此保护肺泡巨噬细胞对改善肺部清除颗粒物功能具有重要意义。该文综述了PM2.5对肺泡巨噬细胞的细胞毒性、吞噬能力、细胞因子释放、细胞凋亡及氧化应激性等方面的影响,为进一步从机制上阐述PM2.5对人体健康的危害提供理论参考。PM2.5 causes extensive attention in China due to its negative influence on atmosphere environment and human health. Alveolar macrophage is of great importance in proteeling respiratory system and lung tissue from particulate matter invasion. Therefore PM2.5 is believed to cause serious respiratok＇y problems once the function of alveolar maerophage is destroyed during the long-term exposure to PM2.5. This review mainly described the effects of PM2.5 on alveolar macrophage function,especially for cytotoxicily, phagocytic function, cytokbm release, apoptosis, oxidative stress.

关 键 词：空气污染 PM2 5 肺泡巨噬细胞 

分 类 号：R994.6[医药卫生—毒理学]