静电纺丝法制备多层复合骨引导再生微纳米纤维膜  

Fabrication of Multi-layer Composite Guided Bone Regeneration Micro-Nano Fiber Membranes by Electrospinning

作　　者：汤玉斐[1] 谢高伟[1] 赵康[1] 刘欣宇[1] 马楚凡[2] 

机构地区：[1]西安理工大学材料科学与工程学院,西安710048 [2]第四军医大学口腔医学院修复科,西安710032

出　　处：《材料导报》2013年第24期82-87,共6页Materials Reports

基　　金：教育部高等学校博士学科点专项科研基金(20106118110002);陕西省自然科学基金重点项目(2012JZ6001);陕西省教育厅科研计划项目(12JK0428)

摘　　要：为了使骨引导再生膜同时具有阻隔、药物缓释及诱导骨生长功能，采用静电纺丝法制备了多层复合骨引导再生微纳米纤维膜，依次为上层载药胶原微纳米纤维膜、中层PCL微纳米纤维膜和下层胶原／PCL／nHA复合微纳米纤维膜，并对各层膜的微观形貌、相组成、释药性能、疏水特性和体外降解性能进行了研究。结果表明：通过静电纺丝可以获得具有多层结构的复合骨引导再生微纳米纤维膜，其中上层膜中药物分布均匀，胶原质量分数为5％时的释药时间为1900min；中层膜的孔尺寸在200-300nm且具有较好的疏水性，能够阻止上下两层膜间的成分扩散；胶原／PG。质量比为1：1、nHA的含量为30％的下层膜成分均匀，降解速率适中并具有较好的矿化作用。Multi-layer composite guided bone regeneration micro-nano fibers membranes were fabricated by electrospinning to improve their properties, which have drug-loaded collagen micro-nano fibers membrane （upper la- yer）, PCL micro-nano fibers membrane （middle layer） and collagen/PCL/nHA composite micro-nano fibers mem- brane （under layer） and were used as a barrier, drug delivery and induction of bone growth. The morphologies, phase composition, drug release behavior, hydrophobic properties and in vitro degradation of miero-nano fibers membranes were investigated. The results show that, guided bone regeneration micro-nano fibers membrane with multi-layer structure was obtained via electrospinning. Amoxicillin is well distributed in upper layer, and the drug release time was 1900 min when the collagen mass fraction was 5~//oo. The middle layer＇s pores were 200--300 nm with hydrophobic property, which can prevent the components diffusion between the upper and under layers. Composite of under layer was uniform when the mass ratio of collagen and PCL was 1 ： 1,nHA content was 30%. Under layer＇s degradation rate is moderate with mineralization.

关 键 词：多层微纳米纤维膜 骨引导再生 静电纺丝 药物释放 骨诱导作用 

分 类 号：TB332[一般工业技术—材料科学与工程]