微小RNA在肥胖中的研究进展  

Roles of microRNAs in obesity regulation

作　　者：王杨[1] 沈卫星[1] 卢圣锋[1] 朱冰梅[1] 

机构地区：[1]南京中医药大学针药结合省部共建教育部重点实验室,210023

出　　处：《中国糖尿病杂志》2014年第1期89-92,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81273838);教育部博士点基金(20123237110001);江苏省教育厅重大项目(11KJA360003)

摘　　要：肥胖已成为全球性的健康问题，深入了解其分子机制具有重要意义。miRNAs是一类长度约为18-25 nt的内源性非编码RNA，通过转录后修饰，可调控基因表达。越来越多的研究表明，miRNAs在肥胖发生发展过程中扮演重要角色，发现其参与了脂肪细胞分化、肝脏脂质代谢和IR等过程。本文就近年来的相关研究进行总结，并综述如下。Increasing evidences have shown that microRNAs （miRNAs） may play important roles in establishment and development of obesity. miRNAs are a class of endogenous small non-coding RNAs of 18-25 nucleotides. They regulate gene expression through post-transcriptional modification. miRNAs were involved in many biological and pathological processes in obesity, including adipocyte differentiation, hepatic lipid metabolism, and insulin resistance. In this review, miRNAs involving in adipogenesis and lipid metabolism are discussed.

关 键 词：肥胖 微小RNA 脂肪细胞分化 脂质代谢 胰岛素抵抗 

分 类 号：R589.2[医药卫生—内分泌]