沙美特罗对低氧高碳酸性大鼠膈肌疲劳的影响  

Effects of salmeterol on diaphragmatic fatigue induced by hypoxic,hypercapnic acidosis in rat

作　　者：徐旋里[1] 陈莹[2] 杨秋火[2] 谢强敏[2] 

机构地区：[1]杭州市红十字会医院呼吸内科,杭州310004 [2]浙江大学医学院国家医药管理局浙江呼吸药物研究实验室,杭州310031

出　　处：《中国药理学通报》2000年第6期667-669,共3页Chinese Pharmacological Bulletin

摘　　要：目的　探讨沙美特罗对低氧高碳酸性大鼠膈肌疲劳的作用。方法　用低氧高二氧化碳混合气造成膈肌疲劳模型 ,观察沙美特罗 (1× 10 -9～ 1× 10 -6mol·L-1)对膈肌收缩力的影响。结果　沙美特罗 1× 10 -9～ 1× 10 -6mol·L-1均提高了力 频率关系曲线中 40～ 12 0Hz下的张力 ,而对膈肌的颤搐特性、维持张力、肌刺张力无影响。结论　沙美特罗对低氧高碳酸所致的大鼠膈肌的高频疲劳有一定的改善作用。AIM To study the effects of salmeterol on diaphragmatic fatigue in vitro induced by hypoxic,hypercapnic acidosis. METHODS The fatigued diaphragm model was set up with 21% O 2、12% CO 2、67% N 2 gas mixture,the effects of salmeterol on fatigued diaphragmatic contractility were investigated with rat phrenic nerve diaphragm preparations. RESULTS Salmeterol 1×10 -9 ～1×10 -6 mol·L -1 increased diaphragmatic contractile force at the frquencies 40 Hz～120 Hz ( P <0 05),but no significant effects were observed with it on PTT、TPT、1/2RT、maintaining tension、or tension by muscle stimulation. CONCLUSION Salmeterol can improve high frequency fatigue due to hypoxic,hypercapnic acidosis to some extent.

关 键 词：低氧高碳酸 膈肌疲劳 沙美特罗 药物疗法 平喘药 

分 类 号：R974.3[医药卫生—药品] R565.65[医药卫生—药学]