三硝基甲苯作业工人和慢性乙型肝炎患者血清磷酸化酶a活性的变化  

The activity changes of serum phosphorylase A in the workers exposed to trinitrotoluene and in the patients suffering from chronic hepatitis B

作　　者：崔京伟[1] 常元勋[1] 李珠明[2] 贝涛 刘文献 李迅 杨振中 

机构地区：[1]北京医科大学劳动卫生教研室,北京100083 [2]北京医科大学劳动卫生专业 [3]河南省平顶山煤炭卫生学校 [4]河南省职业病防治所

出　　处：《中国职业医学》2000年第6期30-31,共2页China Occupational Medicine

摘　　要：目的　探讨血清磷酸化酶a活性对评价TNT早期肝损伤的意义。方法　测定TNT接触组、慢性乙型肝炎患者和慢性HBsAg携带组血清磷酸化酶a活性。结果　TNT生产车间空气中TNT浓度均超过国家最高容许浓度 (MAC =1mg/m3) ,工人皮肤污染较严重。TNT接触组和慢性乙型肝炎患者血清磷酸化酶a活性与对照组比较无差异。结论　推测接触组血清磷酸化酶a活性的升高可能与TNT所致肝损伤有一定关系。如果TNT作业工人乙型肝炎病毒血清学标志为阴性 ,建议用其血清磷酸化酶a活性升高作为评价TNT早期肝损伤的指标。Objective To study the changes of serum phosphorylase A activities in evaluating early liver damage induced by TNT.Methods The phosphorylase A activities of the TNT exposed workers group, of the patients suffering from chronic hepatitis B and of the control group were determined.Results The average TNT concentrations in the air of workshop were beyond the national maximum allowable concentration (MAC=1 mg/m 3) and the skin of TNT exposed workers were seriously contaminated with TNT. The activities of phosphorylase A in serum of both the TNT exposed worker group and the patient group suffering from chronic hepatitis B were higher than those in the control group; the activities of serum phosphorylase A of the chronic HBsAg carries group were close to the level of those in the control group.Conclusion It seemed that the increase of serum phosphorylase A activities related with liver damage. If the marker hepatitis B virus in the serum of TNT exposed workers was negative, it was suggested that the increase of serum phosphorylase A activities in TNT exposed workers might act as an index for detecting early liver damage induced by TNT.

关 键 词：三硝基甲苯 磷酸化酶A 作业工人 慢性乙型肝炎 

分 类 号：R135.12[医药卫生—劳动卫生] R512.62[医药卫生—公共卫生与预防医学]