中药复方治疗慢性肺源性心脏病肺动脉高压临床研究  

Clinical Research of Traditional Chinese Medicine Compound in Treatment of Pulmonary Hypertension of Chronic Cor Pulmonale

作　　者：曲妮妮[1] 刘浩[1] 马丽佳[1] 赵克明[1] 郑忻[1] 杨丽[1] 庞立建[1] 席瑞[1] 

机构地区：[1]辽宁中医药大学附属医院呼吸科,辽宁沈阳110000

出　　处：《中华中医药学刊》2014年第2期314-316,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：辽宁省科技厅计划项目(2011225016)

摘　　要：目的:观察中药复方对慢性肺源性心脏病气虚血瘀兼痰阻患者的治疗作用。方法:随机纳入慢性肺源性心脏病气虚血瘀兼痰阻240例患者,分为对照组、治疗组各120例,常规治疗包括给予吸氧、抗感染等,对照组予常规治疗基础上加硝苯地平口服,治疗组予常规治疗加中药复方,疗程2周。观察治疗前后的临床症状、体征、平均肺动脉压(MPAP)、左室射血分数(LVEF)、动脉血氧分压(Pa02)、动脉血二氧化碳分压(PaC02)等指标。结果:与对照组相比,治疗组的临床症状明显改善,总有效率(96.7%)显著的高于对照组(86.7%),差异有统计学意义(P<0.05),2组治疗后的MPAP,LVEF,Pa02,PaC02均较治疗前显著改善(P<0.05,P<0.01),且中药复方组MPAP,Pa02,改善优于对照组(P<0.05)。结论:中药复方可以有效缓解慢性肺心病气虚血瘀兼痰阻患者的临床症状及体征,动脉血氧分压,左室射血分数,降低平均肺动脉压。Objective：To observe the effect of Chinese herbal compound prescription on the pulmonary heart disease （PHD） patients with pattern of syndrome of Qi deficiency and blood stasis combining phlegm. Methods ：240 chronic PHD patients of Qi deficiency and blood stasis combining phlegm syndrome were randomly divided into treatment group （120 cases） and control group（ 120 cases）. Control group received Nifedipine orally based on the routine treatment which included oxygen inhalation and anti - infective treatment. Treatment group orally received Chinese herbal compound a dose once a day based on the control group＇s treatment, each for two weeks. The clinical symptoms, signs, mean pulmonary artery pressure （MPAP） ,left ventricular ejection fraction （LVEF） , arterial blood oxygen partial pressure （ PaO2 ） , arterial blood CO2 partial pressure （ PaCO2 ） were observed before and after treatment. Results ： 1. Compared with the control, the clinical symptoms apparently improved, with the total effective rate （96.7%） significantly higher than those in the control group （86.7%）,meanwhile, the difference was statistically significant （P 〈 0.05）. 2. The MPAP, LVEF,PaO2 and PaCO2 of both groups were significantly improved after the treatment （P 〈 0.05, P 〈 0. 01 ）, and treatment group improved much better than the control group in PaO2 and MPAP （ P 〈 0. 05 ）. Conclusion ： Chinese herbal compound prescription can effectively relieve the clinical symptoms and signs, improve PaO2 and LVEF and lower MPAP in PHD patients with Qi deficiency and blood stasis combining phlegm.

关 键 词：中药复方 肺心病 益气活血化痰 

分 类 号：R256.1[医药卫生—中医内科学]