抗结核药物导致药物性肝损害的中医证候学聚类分析  

Clustering Analysis on TCM Syndrome of Anti-Tuberculosis-Drug-Induced Liver Injury

作　　者：马国玲[1] 崔岩飞[1] 韩颖[1] 胡钦[1] 李凫坚[1] 牟新[1] 

机构地区：[1]杭州市红十字会医院结核病治疗中心,浙江杭州310003

出　　处：《中华中医药学刊》2014年第2期320-322,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划项目(2009CA084)

摘　　要：目的:探讨抗结核化疗药物造成肝损伤患者的中医证候学规律,为该病的中医药规范化治疗提供依据。方法:采用中医证候调查表对261例抗结核化疗药物造成肝损伤患者进行调查,证候分型的判定采用聚类分析的方法。结果:对证候学初步量表进行聚类分析可以得出抗结核化疗药物造成肝损伤的5个常见证型,恰好反映了临床相应证型的内涵。结论:采用中医证候调查表的形式进行流行病学调查结合系统聚类分析的方法对中医证候学研究具有一定的实用价值。Objective ：To investigate the syndrome of TCM in antituberculous chemotherapy drug-induced liver injury patients, and to provide the basis for the TCM standardizing treatment. Methods ：261 cases of antituberculous chemotherapy drug- induced liver injury patients were investigated by using Chinese medicine syndrome questionnaire, and the syndrome of TCM used cluster analysis. Results ： Though the clustering analysis, we can acquire 5 common syndromes of liver injury by using Chinese medicine syndrome questionnaire, exactly reflecting the connotation of the corresponding clinical syndromes. Conclusion：The Chinese medicine syndrome questionnaire in the form of epidemiologieal investigation combined with the method of system cluster analysis has some practical value to study TCM syndrome.

关 键 词：抗结核疗法 药物性肝损害 中医证候学 聚类分析 

分 类 号：R284.3[医药卫生—中药学]