三七花总皂苷对自发性高血压大鼠的降压作用研究  

Research of Panax Notoginseng Flower Saponins' Antihypertensive Effect on Spontaneous Hypertension Rats

作　　者：曹敏[1] 楼丹飞[2] 王国印[1] 王佑华[1] 周端[1] 周莉[1] 聂恒[1] 梁逸强[1] 

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]上海市中医医院,上海200071

出　　处：《中华中医药学刊》2014年第2期367-369,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：上海市高新技术产业科技开发基金项目(沪创新J-58)

摘　　要：目的:观察三七花总皂苷对自发性高血压大鼠(SHR)血压、心率的影响。方法:以SHR为研究对象,ACL-NIBP鼠尾无创血压测量分析系统录给药前后血压及心率的变化。结果:三七花总皂苷对SHR收缩压、舒张压有一定降低作用(P<0.05,P<0.01),存在剂量相关性,但对心率影响小。结论:七花总皂苷对SHR大鼠具有降低血压作用。Objective：To study the influence of panax notoginseng flower saponins （PNFS） on blood pressure and heart rate of spontaneous hypertension rats （SHR）. Methods：Blood pressure and heart rate of the rats were recorded and calculated respectively by ACL - NIBP system before and after PNFS treatment. Results ： Systolic pressure and diastolic pressure were declined significantly （P 〈 0. 05, P 〈 0.01 ）, while the heart rate had no significant changes （P 〉 0. 05 ）. Conclusion： PNFS can down regulate blood pressure in spontaneous hypertension rats significantly.

关 键 词：三七花总皂苷 自发性高血压大鼠 

分 类 号：R285.5[医药卫生—中药学]