不同孕周子痫前期患者血清胱抑素C水平变化的研究  

Study on changes of serum cystatin C levels in patients with different gestational weeks

作　　者：韩静[1] 温华生[1] 初晓丽[1] 黄珍[1] 李学文[1] 戴婉波[1] 

机构地区：[1]广州医学院附属深圳沙井医院产科,广东深圳518104

出　　处：《中国优生与遗传杂志》2014年第1期59-61,共3页Chinese Journal of Birth Health & Heredity

基　　金：广东省深圳市科技计划项目编号:201103081

摘　　要：目的探讨子痫前期患者血清胱抑素C水平变化。方法选取2011年5月-2012年12月在广州医学院附属深圳沙井医院产检子痫前期病例50例纳入研究组,同期选择健康孕妇50例作为对照组,所有观察对象于孕20周、孕24周、孕28周、孕30周、孕34周、孕36周产检时记录血压及尿蛋白结果,同时测量外周血清胱抑素C水平。结果①子痫前期组孕20周时血清胱抑素C水平为0.75±0.12mg/L,对照组为0.59±0.33mg/L,,两组间比较P<0.05,差异有统计学意义。此后,随孕周增加,两组病例间血清胱抑素C水平均有上升趋势,且相同孕周相比均有统计学差异(P<0.05)。②子痫前期组孕28周时收缩压为145.2±19.1mmHg,舒张压为89.5±15.7mmHg,对照组孕28周时收缩压为133.1±17.2mmHg,舒张压为80.4±17.3mmHg,此后随孕周增加,两组病例收缩压及舒张压均呈进行性上升,且相同孕周相比具有统计学差异(P<0.05)。孕20周、孕24周时子痫前期组及对照组相比,舒张压及收缩压无统计学差异(P>0.05)。③子痫前期组首次出现尿蛋白时间为1例28周,10例30周,21例34周,18例36周,对照组没有尿蛋白。结论子痫前期患者孕20周后胱抑素C升高,早于临床血压及尿蛋白改变时间,胱抑素C可能是子痫前期发生预测及肾功能早期损害的敏感指标。Objective ： To investigate the changes of different pregnancy serum cystatin C levels in preeclamptic patients. Methods ： From 2011 May-2012 year in December in Shenzhen Shajing Affiliated Hospital of Guangzhou Medical University examined pre-eclamptic patients. 50 cases included in the study group, select the same period 50 cases of healthy pregnant women as control group, all the observed objects at 20 weeks of pregnancy, pregnant 24 weeks, 28 weeks of pregnancy, pregnant 30 weeks, 34 weeks of preg- nancy, 36 weeks of pregnancy check -ups recorded blood pressure and urinary protein results, simultaneous measurement of serum cystatin C level. Results： ①Preeclampsia group at 20 weeks of serum cystatin C level was 0. 75 ± 0. 12mg/L, 0. 59 ± 0. 33mg/L in the control group, the comparison between two groups, P 〈 0.05, the difference was statistically significant. After that, with the increase of gestational weeks, serum cystatin C levels were two groups increased, and the same gestational weeks were compared statistically sig- nificant difference （ P 〈 0. 05）. ②Preeclampsia 28 weeks pregnant when the systolic blood pressure was 145.2 ± 19.1 mmHg, diastolic blood pressure was 89. 5 ± 15.7mmHg, the control group at 28 weeks, systolic blood pressure was 133.1 ± 17.2mmHg, diastolic blood pressure was 80. 4 ± 17.3mmHg, then increased with gestational age, two cases of systolic and diastolic blood pressure were to rise, and compared the same gestational weeks with statistical difference （P 〈 0. 05 ）. At 20 weeks, 24 weeks of pregnancy, preeclampsia group and compared with the control group, diastolic blood pressure and systolic blood pressure showed no significant difference （P 〉 0.05 ）, the preeclampsia group first appeared in 1 cases of urinary protein in time for the 28 week, 30 week in 10 cases, 21 cases of 34 weeks, 36 weeks in 18 cases, the control group no urine protein. Conclusion： the pregnant women with preeclampsia 20 weeks after elevated cystatin C, early in the clinical b

关 键 词：子痫前期 胱抑素C 蛋白尿 

分 类 号：R714.245[医药卫生—妇产科学]