控制性超排卵治疗对多囊卵巢综合征患者卵母细胞质量的影响  

The influence of controlled ovarian hyperstimulation treatment on polycystic ovary syndrome oocyte quality

作　　者：刘明慧[1] 刘英[1] 王树玉[1] 贾婵维[1] 任国庆[1] 余兰[1] 王丽[1] 杨晓葵[1] 李薇[1] 

机构地区：[1]首都医科大学附属北京妇产医院生殖中心,北京100026

出　　处：《中国优生与遗传杂志》2014年第1期97-99,共3页Chinese Journal of Birth Health & Heredity

基　　金：北京市自然科学基金项目(5122015);北京市科技新星基金项目(H020821200190)

摘　　要：目的探讨辅助生育技术中控制性超排卵治疗对多囊卵巢综合征不孕患者卵母细胞质量的影响。方法对接受GnRH-a长方案降调控制性超排卵的多囊卵巢综合征患者50例(共52个周期),和同期因输卵管因素不孕接受GnRH-a长方案降调的对照组患者57例(共60个周期),观察取卵后卵-冠-丘复合物,对其卵母细胞质量进行评级,比较两组卵母细胞质量、成熟率、受精率、卵裂率、优质胚胎率和妊娠结局。结果 PCOS组3级卵母细胞数、优质胚胎数高于对照组,有显著性差异(P<0.05),而3级卵母细胞率、优质胚胎率与对照组相比无明显统计学差异(P>0.05),PCOS组1级、2级和4级卵母细胞数及比例与对照组相比无明显统计学差异(P>0.05)。PCOS组与对照组卵母细胞成熟率(88.0%vs88.3%)、受精率(79.3%vs 82.1%)、卵裂率(76.9%vs 80.3%)、临床妊娠率(38.5%vs 40.0%)等,差异无明显统计学意义(P>0.05)。结论 PCOS患者经促排卵治疗后,其优质卵母细胞数、优质胚胎数目明显高于正常对照组,能获得与正常对照患者相同的优质卵母细胞率、卵母细胞成熟率、受精率、卵裂率、优质胚胎率及临床妊娠率。Objective ： To investigate the influence of controlled ovarian hyperstimulation treatment on polycystic ovary syndrome o-ocyte quality. Methods： During controll ovarian hyperstimulation with GnRH-a long protocol, 50 patients （52 treatment cycles） with polycystic ovary syndrome and 57 patients （60 treatment cycles） with tubal factor infertility were observed and compared. The oocyte quality of two group were evaluated by observing oocyte - corona - cumulus complex, and the oocyte quality, maturation, fertilization rate, cleavage rate, high-quality embryo rate and pregnancy outcomes were compared further. Results： There are significant differ-ences between PCOS and control group in the number of 3 grade of oocyte and high - quality embryo. However, the ratios of 3 grade of oocyte and high - quality embryo between two groups are undifferentiated. The difference of oocyte maturation rate （88.0% vs 88.3% ）, fertilization rate （79. 3% vs 82. 1% ）, cleavage rate （76. 9% vs 80. 3% ）, clinical pregnancy rate （38. 5% vs 40. 0% ）, ete, was not significant statistically between the two groups （ P 〉 0.05 ）. Conclusion ： The number of high - quality ooeyte and high - quality embryo in PCOS patients is significantly higher than the normal control group. PCOS patients undergoing IVF treatment to pa-tients with normal controls can obtain the same high quality rate of ooeyte, oocyte maturation rate, fertilization rate, cleavage rate, high quality embryo rate and clinical pregnancy rate.

关 键 词：多囊卵巢综合征 卵母细胞质量 辅助生殖技术 

分 类 号：R711.7[医药卫生—妇产科学]