原发性高血压患者血管内皮舒张功能的超声研究  

Studies of Vascular Endothelium Function in Essential Hypertension

作　　者：祖竑[1] 祁芸云[1] 赵玮 欧阳福珍[1] 李湘燕[1] 

机构地区：[1]北京医科大学第一临床医院老年内科,100034

出　　处：《中国超声医学杂志》2000年第12期903-906,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的及方法 :本文应用血管超声技术对 2 8名原发性高血压患者 ( 期 17例 , 期 11例 )和 13名正常人前臂动脉血管内皮依赖性舒张功能进行了定量研究。结果 :高血压 组及 组患者反应性充血后血流介导的血管扩张 (FMD)均较正常人明显下降 (P<0 .0 5 ,P<0 .0 1)。高血压 组与 组患者充血反应 (RH)均较正常人明显减少 (P<0 .0 5 ) ,而平滑肌介导的血管扩张功能 (GNT- MD)在三组中无差异。正常人给予左旋精氨酸 (L - Arg)后 ,FMD及 RH增加 ,与用药前相比有明显差异 (P<0 .0 5 ) ,平滑肌介导的血管扩张功能 (GNT- MD)在用药前后无差异 ,而两组高血压患者给予 L - Arg后 ,FMD,RH及 GNT- MD在用药前后均无差异。结论Objective and Methods:We used vascular ultrasound to observe relaxing factors derived from the brachial artery endothelium to mediate relaxation of vasculature,the function changed by infusing L Arg in essential hypertension.Twenty eight patients with essential hypertension and thirteen normal subjects were recruited for the study.The hypertension group was divided into two groups,(Ⅰ)phase one of hypertension,17 cases.(Ⅱ)phase two of hypertension,11 cases.Results:Flow mediated dilatation(FMD) and reactive hyperemia(RH) were decreased in essential hypertension groups compared with those of control( P <0 05, P <0 01).In control subjects,the infusion of L Arg significantly augmented FMD and RH,higher than those before infusion( P <0 05).In hypertension patients,the infusion of L Arg did not modify the response of FMD and RH.Conclusions:Vascular responses to endothelium dependent and independent to stimuli in systemic arteries can be studied by vascular echocardiography.

关 键 词：原发性高血压 血管内皮舒张功能 血管超声 

分 类 号：R544.1[医药卫生—心血管疾病] R445.1[医药卫生—内科学]