白细胞介素6在胎膜早破孕妇母血、羊水、脐血中的水平及临床意义的研究  

Interleukin-6 Levels in Maternal Serum, Umbilical Cord Serum and Amniotic Fluid in Patients with Premature Rupture of Membranes and Clinical Implication

作　　者：邓飞涛[1] 鲁秋云[2] 

机构地区：[1]同济医科大学附属协和医院妇产科,武汉430022 [2]同济医科大学附属同济医院妇产科,武汉430030

出　　处：《同济医科大学学报》2000年第6期547-549,共3页Acta Universitatis Medicinae Tongji

摘　　要：分别采用放免法和ＥＬＩＳＡ法测定２组孕妇羊水和母血、脐血白细胞介素６（ＩＬ－６）水平，产后行胎膜病理检 查。结果表明：胎膜早破组母血、脐血和羊水ＩＬ－６水平均明显高于对照组（Ｐ＜０．０１）；随破膜时间延长和胎膜病检炎 症程度加重，母血和羊水 ＩＬ－６水平逐步升高（Ｐ＜０．０１）；胎膜早破孕妇，抗生素组较非抗生素组母血、羊水ＩＬ－６水平 显著降低（Ｐ＜０．０１）。比较监测绒毛羊膜炎各指标和方法的临床价值发现：采用ＥＬＩＳＡ法测母血ＩＬ－６是早期监测胎膜 早破孕妇发生绒毛羊膜炎的一种较敏感、方便的方法和指标。IL-6 levels in amniotic fluid and maternal and umbilical cord serum were measured by radioim- munoassay or enzyme-linked immunosorbent assay (ELISA) respectively in the two groups of pregnant wom- en. Chorioamnionitis was histopathologically confirmed after delivery. The results showed that the levels of IL- 6 in maternal serum, umbilical cord serum and amniotic fluid were significantly higher in premature rupture of membranes (PROM) group than in the control group (P<01 ). The longer the duration from rupture of mem- branes to delivery was, the more serious chorioamnionitis was, and the higher the levels of IL-6 in serum and amniotic fluid were. In the patients with PROM, the IL-6 levels in maternal serum and amniotic fluid were sig- nificantly lower in the patients treated with antibiotics than those non-treated with antibiotics. The comparison of the clinical values of various parameters and methods for monitoring chorioamnionitis revealed that determina- tion of the levels of IL-6 in maternal serum by ELISA was a more sensitive and more convenient diagnostic test for rapid prenatal screening of chorioamnionitis in the patients with PROM.

关 键 词：胎膜早破 绒毛羊膜炎 白细胞介素6 孕妇 母血 

分 类 号：R714.433[医药卫生—妇产科学] R714.62[医药卫生—临床医学]