Wnt/β-catenin信号通路与胰腺癌相关性的研究进展  

Relationship between Wnt/β-catenin signaling pathway and pancreatic cancer

作　　者：崔雨萌(综述)[1] 李骢(审校)[2] 

机构地区：[1]大连医科大学2009级七年制硕士研究生班,116044 [2]大连医科大学病理生理教研室

出　　处：《肿瘤研究与临床》2013年第12期856-858,共3页Cancer Research and Clinic

摘　　要：Wnt信号通路是调节细胞增殖、分化及移型的经典通路之一.Wnt蛋白可与多种不同Wnt蛋白受体结合,激活细胞内不同的信号通路,研究证实Wnt/β-catenin信号通路与胰腺癌的发生发展密切相关.对Wnt/β-catenin信号通路在细胞周期、细胞凋亡、肿瘤干细胞及血管生成方面对胰腺癌发生发展的影响进行综述.Wnt signaling pathway is one of canonical pathways that can regulate diverse processes such as cell proliferation,differentiation,migration.Interaction between Wnt ligands and Wnt receptors results in an activation ofdifferent intracellular signaling pathways,and Wnt/β-catenin signaling pathway has been proved to have a close relationship with pancreatic cancer.This review presents a brief overview of Wnt/β-catenin signaling pathway in the mechanism of the tumorigenesis of the pancreatic cancer at deregulation of cell cycle,apoptosis,cancer stem cells and angiogenesis.

关 键 词：胰腺肿瘤 WNT Β-CATENIN信号通路 细胞周期 细胞凋亡 肿瘤干细胞 血管生成 

分 类 号：R282.71[医药卫生—中药学]