脂多糖诱导的脑损伤中橙皮苷对小鼠开场行为的干预作用  

Interference of Hesperidin on the Behavior of Mice in Open Field after Infective Brain Injury Induced by Lipopolysaccharide

作　　者：吴健[1] 刘红芝[1] 温相如[1] 付燕燕[1] 孙颖[2] 张磊[2] 张芳[1] 王淑玲[3] 刘永民[1] 刘永海[2] 宋远见[1] 

机构地区：[1]徐州医学院神经生物学研究中心,江苏徐州221004 [2]徐州医学院附属医院神经内科,江苏徐州221000 [3]徐州医学院附属市立医院呼吸科,江苏徐州221000

出　　处：《山东工业技术》2013年第13期9-10,共2页Journal of Shandong Industrial Technology

基　　金：国家自然科学基金项目(编号:31100762;81371300);江苏省高校自然科学研究项目(编号:11KJB310013;13KJB310021);徐州医学院院长基金项目(编号:2012KJZ06);徐州医学院院课题(编号:2009KJ05)

摘　　要：目的:研究橙皮苷对脂多糖(LPS)诱导的感染性脑损伤小鼠开场行为的干预作用。方法:将45只3周龄ICR小鼠随机平均分为三组,即生理盐水组(Saline)、脂多糖组(LPS)、脂多糖+橙皮苷组(Hesp),每组15只,以ZH-ZFT型联合开场实验视频分析系统考察各组小鼠活动路程和穿格线次数的情况。结果:相对于Saline组,LPS组小鼠的活动路程明显缩短,穿格线次数显著减少(P<0.05);相对于LPS组,Hesp组小鼠的活动路程明显延长,穿格线次数显著增加(P<0.05)。结论:橙皮苷能够显著增强LPS诱导的感染性脑损伤小鼠在开场环境中的活动能力。Objective： To determine the interference of Hesperidin on the behavior of mice in open field after infective brain injury induced by lipopolysaccharide （LPS）. Methods： 45 healthy ICR male mice of 3-week-old were randomly divided into 3 groups： Saline group, LPS group and Hesp group. There were 15 mice in each group. Every mouse was observed in open field to get data of moving distance and the number of crossing line. Results： Compared with mice of Saline group, mice of LPS group had significantly both shorter moving distance and less number of crossing line （P〈0.05）; compared with LIPS group, mice of Hesp group moved significantly longer distance and crossed lines frequently （P〈0.05）. Conclusion： Hesperidin could significantly improve physical performance of mice with infective brain iniurv induced by LPS in ooen field test.

关 键 词：感染性脑损伤 橙皮苷 开场行为 

分 类 号：R285.5[医药卫生—中药学]