整合子-基因盒系统与细菌多重耐药关系的研究进展  

Evaluation of effects of intervention on health literacy in Yuhuatai District in Nanjing

作　　者：张宏萍[1] 练维[1] 汪晓莺[2] 

机构地区：[1]江苏省南通市疾病预防控制中心微生物检验科,226007 [2]南通大学医学院

出　　处：《职业与健康》2014年第1期133-135,139,共4页Occupation and Health

基　　金：南通市科技基金项目[项目编号:K2010044(2010 K应用研究)]

摘　　要：细菌由单一耐药转为多重性耐药,导致抗生素的疗效下降,已成为临床用药和治疗的一大困扰难题。整合子是保守、可移动的基因元件,其在整合酶的介导下,可通过位点特异的重组系统捕获外源性的基因盒并使之表达;同时整合子可定位于质粒上,或者自身作为转座子的一部分参与转移,使耐药基因在细菌种间和种内发生传播。目前报道较多的有Ⅰ、Ⅱ、Ⅲ、Ⅳ类整合子,前3种已被证明与细菌耐药性相关,整合子-基因盒系统理论的建立为人们深入研究细菌耐药机制提供了新的方向。作者对整合子-基因盒系统的起源、结构、分类分布、转移机制及最新的生物学检测方法等方面进行综述。The decrease of antibiotics efficacy induced by the transformation of single-drug resistant bacteria to multi-drug resistant bacteria can has become a serious problem in clinical medicine and treatment. Intergron is a conservative and movable genetic ele-ment which can express via capturing exogenous gene by cassette site-specific recombination system under the mediation of the inte-grase. Intergron can make resistant gene transfer between bacterial, species and within species via locating in the plasmid or be in-volved in transfer as a part of transposon. Currently, there are many reports about class Ⅰ , Ⅱ, Ⅲ, Ⅳ integron, the first 3 has been verified to be associated with bacterial resistance. The established theory of intergron-gene cassette provides a new direction for in-depth study of the mechanism of bacterial resistance. This paper summarize the origin, structure, classification and distribution , transfer mechanisms and the latest biological detection method of intergron-gene cassette.

关 键 词：整合子 基因盒 多重耐药 

分 类 号：R978[医药卫生—药品]