血清IL-17和IL-23与HIV/AIDS患者机会性感染的关系  

The relationship between opportunistic infections of HIV/AIDS patients and serum concentration of interleukin-17 and interleukin-23

作　　者：陈婵[1] 李孟英[1] 谭可平[1] 甘琼萍[1] 陆晖[1] 沈扬林 覃国琦[1] 

机构地区：[1]解放军第303医院感染科,南宁530021

出　　处：《中华实验和临床感染病杂志（电子版）》2013年第5期17-20,共4页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：广西卫生厅自筹经费科研课题(Z2011008)

摘　　要：目的检测人类免疫缺陷病毒感染者和艾滋病(AIDS)患者血清白细胞介素-17(IL-17)、白细胞介素-23(IL-23)水平,探讨其与患者发生机会性致病菌感染的关系。方法 55例AIDS患者,应用ELISA法检测血清IL-17、IL-23水平,结合其临床资料分析与机会性感染的关系。结果 55例患者中有44例发现机会性致病菌感染,11例未发生机会性致病菌感染。感染组IL-17水平较非感染组高[(92.53±158.45)pg/ml vs(10.21±19.17)pg/ml,P<0.01],血清IL-23水平差异无统计学意义。12例肺孢子菌感染者的IL-17水平较未感染者明显降低[(19.78±27.95)pg/ml vs(91.78±160.78)pg/ml,P<0.01]。血清IL-17、IL-23水平与疾病预后无关。结论 IL-17可能参与HIV/AIDS患者发生机会性感染的免疫机制,低IL-17水平可能导致患者对肺孢子菌的清除能力下降。Objective To investigate the relationship between opportunistic infections of HIV/AIDS patients and the serum levels of interleukin-17 （IL-17） and interleukin-23 （IL-23）. Methods The serum samples and the clinical information of 55 cases with HIV infection or AIDS patients were collected. The serum concentrations of IL-17 and IL-23 were measured with enzyme linked immunosorbent assay （ELISA）. Results There were 44 cases suffering with opportunistic infections in total 55 cases. The serum level of IL-17 in patients with opportunistic infections was significantly higher than that in the group without opportunistic infections [（92.53 ± 158.45） pg/ml vs （10.21 ± 19.17） pg/ml, P 〈 0.01], but there was no statistical difference in the serum IL-23 concentrations. The serum level of IL-17 in 12 cases with pneumocystis pneumonia was lower than that in the group without pneumocystis pneumonia [（19.78 ± 27.95） pg/ml vs （91.78 ± 160.78） pg/ml, P 〈 0.01]. The correlation analysis was negative between the prognosis of 55 cases and serum IL-17, IL-23. Conclusions IL-17 may play a role in the immunologic mechanism of HIV/AIDS patients with opportunistic infections. Lower serum IL-17 may result in lower clearance of pneumocystis pneumonia.

关 键 词：人类免疫缺陷病毒 艾滋病 白细胞介素-17 白细胞介素-23 机会性感染 

分 类 号：R512.91[医药卫生—内科学]