维吾尔族和汉族丙型肝炎患者T淋巴细胞亚群对比分析  

Analysis on T lymphocyte subpopulation between Uygurs and Han Chinese patients with hepatitis C

作　　者：雷群[1] 陈丽霞[1] 郭淑丽[1] 陈程[1] 

机构地区：[1]新疆维吾尔自治区人民医院临检中心,乌鲁木齐830001

出　　处：《中华实验和临床感染病杂志（电子版）》2013年第5期54-56,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的探讨分析维吾尔族和汉族丙型肝炎患者外周血中T淋巴细胞亚群的表达及意义。方法对247例丙型肝炎患者外周血采用酶联免疫吸附法检测抗-HCV、荧光定量聚合酶链反应法检测丙型肝炎RNA和流式细胞仪法对T淋巴细胞亚群进行分析。结果维吾尔族丙型肝炎患者CD4+T(31.23±17.16)%和CD4+/CD8+(0.65±0.37)%均低于汉族患者(41.25±16.13)%和(0.92±0.38)%,维吾尔族丙型肝炎患者CD8+T(60.25±26.36)%高于汉族患者(52.91±22.59)%,差异均有统计学意义(t=4.65、5.52、2.30,P=0.00、0.00、0.02),但两民族患者间抗-HCV阳性率差异无统计学意义(χ2=2.57,P=0.11)。结论维吾尔族丙型肝炎患者与汉族患者免疫功能不同,CD4+T淋巴细胞免疫功能降低,可能是HCV持续感染和免疫耐受的重要原因之一。HCV持续感染患者的T淋巴细胞亚群的变化,加重了丙型肝炎的慢性化,临床应加以重视。Objective To explore the expression and significance of T lymphocyte subpopulation in peripheral blood of Uygur and Han Chinese patients with hepatitis C. Methods Total of 247 cases with hepatitis C, serum levels of antibody of HCV were detected by enzyme-linked immunosorbent assay, HCV RNA were detected by fluorescence quantitative polymerase chain reaction, and T lymphocyte subpopulation were analysed by flow cytometry. Results The rates of CD4＋% and CD4＋/CD8＋ were markedly lower in Uygur patients [（31.23 ± 17.16） and （0.65 ± 0.37）]% than those of the Han Chinese patients [（41.25 ± 16.13） % and （0.92 ± 0.38）]%, and the rates of CD8＋% were markedly higher in Uygur patients （60.25 ± 26.36）% than （52.91±22.59）% of Han Chinese patients, and there were significant differences （t = 4.65, 5.52, 2.30; P = 0.00, 0.00, 0.02）. Conclusions Our study suggest there could be different in immune function of hepatitis C between Uygur and Han Chinese patients, the positive rate of HCV RNA were markedly higher in Uygur patients, and the lower immune function of CD4＋ T lymphocyte maybe one of the major reasons for continuous HCV infection and immunologic tolerance, the changes of lymphocyte subpopulation in patients with continuous HCV infection contribute to the progression of chronic hepatitis C and clinical should pay attention to the characteristics.

关 键 词：HCV抗体 肝炎RNA丙型 淋巴细胞亚群T 

分 类 号：R512.63[医药卫生—内科学]