检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:YAN Hao YUE Pan LI ZhiFen GUO ZhiFo LU ZhongLin
机构地区:[1]Key Laboratory of Theoretical and Computational Photochemistry,Ministry of Education [2]College of Chemistry,Beijing Normal University
出 处:《Science China Chemistry》2014年第2期296-306,共11页中国科学(化学英文版)
基 金:supported by the Program for New Century Excellent Talents in Universities(NCET-08-0054);the National Natural Science Foundation of China(20972019)
摘 要:Bifunctional molecules containing macrocyclic polyamine [12]aneN3 and carbazol units, 1-4, have been efficiently synthe sized and fully characterized. Through gel electrophoresis, atomic force microscopy, and dynamic light scattering experiments, compounds 3 and 4b bearing both [12]aneN3 and carbazol moieties showed effective DNA condensation ability at the concen- tration of 80 jaM. Investigations from EB displacement fluorescence spectra, viscosity titration, and ionic strength effects re vealed that the effective DNA condensation comes from the appropriate combination of carbazol and [12]aneN3 units in the bifunctional molecules, and the DNA condensation process is reversible. The incorporation of triazole units in the molecules clearly reduced the cytotoxicity.Bifunctional molecules containing macrocyclic polyamine[12]aneN3 and carbazol units,1 4,have been efficiently synthesized and fully characterized.Through gel electrophoresis,atomic force microscopy,and dynamic light scattering experiments,compounds 3 and 4b bearing both[12]aneN3and carbazol moieties showed effective DNA condensation ability at the concentration of 80μM.Investigations from EB displacement fluorescence spectra,viscosity titration,and ionic strength effects revealed that the effective DNA condensation comes from the appropriate combination of carbazol and[12]aneN3units in the bifunctional molecules,and the DNA condensation process is reversible.The incorporation of triazole units in the molecules clearly reduced the cytotoxicity.
关 键 词:DNA condensation macrocyclic polyamines CARBAZOLES TRIAZOLE gel electrophoresis AFM
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.145