透明质酸、曲安萘德关节腔内注射治疗膝骨性关节炎  

Treatment of knee osteoarthritis with hyaluronic acid and triamcinolone acetonide

作　　者：吴文涛 赵鑫 余袁媛 邹爽 瞿科斌 

机构地区：[1]四川绵阳404医院骨科,四川绵阳621000

出　　处：《中南药学》2013年第12期922-924,共3页Central South Pharmacy

摘　　要：目的 探讨透明质酸、曲安萘德关节腔内注射治疗膝骨性关节炎的临床效果。方法 选取2011年1月～2012年12月本院收治的膝骨性关节炎患者共100例,随机分为治疗组和对照组,2组患者均采用常规的治疗方法,而治疗组在此基础上于关节腔内注射透明质酸钠,对照组于关节腔内注射曲安奈德。结果 治疗1个疗程后2组患者的临床症状均获得改善,但两者疗效差异不存在统计学意义（94.00%vs 84.00%,P〉0.05）;2组患者治疗后7 d、1个月和3个月的Lequesne评分均明显低于治疗前,且治疗后7 d、1个月治疗组患者的Lequesne评分明显低于对照组患者,差异均存在统计学意义（P〈0.05）;随访6个月后治疗组患者的临床总有效率明显高于对照组（84.00%vs 38.00%,P〈0.05）。结论 关节腔内注射透明质酸和曲安奈德治疗膝骨性关节炎的短期疗效相当,但透明质酸的远期疗效明显高于曲安奈德。Objective To determine the effect of hyaluronic acid and tfiamcinolone acetonide on knee osteoarthritis. Meth- ods Totally 100 patients with knee osteoartbxitis from Jan 2011 to Dec 2012 were divided into 2 groups. The 2 groups both took common therapy. The therapy group used hyaluronic acid via intraarticular injection while the control group had triam- cinolone acetonide via intraarticular injection. Results The clinlcal symptoms of the 2 groups were both improved, but the effect of the 2 groups had no significant difference （94.00% vs 84.00%, P 〉 0.05）. The Lequesne score of the 2 groups at 7 d, 1 month and 3 months after the therapy was all lower than before, and the Lequesne score of the therapy group at 7 d and 1 month after the therapy was lower than that in the control group （P 〈 0.05）. The total effective rate in the therapy group 6 months after the therapy was higher than that in the control group （84.00% vs 38.00%, P 〈 0.05）. Conclusion The short- term efficacy of hyaluronic acid and triamcinolone acetonide via intraarticular injection on knee osteoarthritis is no different, but the long-term efficacy of hyaluronic acid is obviously better than that of triamcinolone acetonide.

关 键 词：透明质酸 曲安萘德 关节腔内注射 膝骨性关节炎 

分 类 号：R969.4[医药卫生—药理学]