血清IL-25与HIV合并机会性感染的相关性  

Relationships between serum concentration of interleukin-25 and opportunistic infections in patients with HIV infection

作　　者：陈婵[1] 李孟英[1] 谭可平[1] 甘琼萍[1] 陆晖[1] 沈扬林 覃国琦[1] 

机构地区：[1]解放军第303医院感染科,南宁市530021

出　　处：《中华实验和临床感染病杂志（电子版）》2013年第6期47-50,共4页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：广西卫生厅自筹经费科研课题(No.Z2011008)

摘　　要：目的探讨人类免疫缺陷病毒(HIV)感染者血清IL-25水平与机会性感染的关系。方法收集55例HIV感染者的临床资料,并应用ELISA法检测血清IL-25浓度,流式细胞术检测CD4+T细胞计数,分析两者与HIV感染者发生机会性感染的相关性。结果 55例患者中有44例(80.00%)发生机会性致病菌感染,其中26例(47.27%)发生口腔念珠菌感染。发生机会性感染组患者血清IL-25水平较未发生感染组高[(946.45±1652.84)pg/ml vs(107.58±167.33)pg/ml,P<0.01),CD4+T细胞计数降低[(87.54±110.60)cell/μl vs(298.60±211.91)cell/μl,P<0.05)。发生口腔念珠菌感染组较未发生感染组患者血清IL-25增高[(1247.78±1877.48)pg/ml vs(358.09±944.31)pg/ml,P<0.05),CD4+T细胞计数降低[(48.56±74.90)cell/μl vs(200.04±182.79)cell/μl,P<0.05)。相关性分析显示,IL-25浓度、CD4+T细胞计数分别与发生机会性感染、口腔白色念珠菌感染呈正相关、负相关(P<0.01)。结论 IL-25可能参与HIV感染者发生机会性感染后的免疫反应,高IL-25水平可能与HIV感染者易患机会性感染、口腔念珠菌感染有关。Objective To investigate the relationships of serum concentration of interleukin-25 （IL-25） and opportunistic infections of patients with HIV infection. Methods The serum samples and the clinical information of 55 cases with HIV infection were collected. The serum concentrations of IL-25 and CD4＋ T-cell count were measured by enzyme linked immunosorbent assay （ELISA） and flow cytometry, respectively. Results There were 44 cases （80.00%） suffering with opportunistic infections among 55 cases and 26 cases （47.27%） were infected with oral candidiasis. Higher serum level of IL-25 [（946.45 ± 1652.84） pg/ml vs （107.58 ± 167.33） pg/ml, P 〈 0.01] and lower CD4＋ T-cell count [（48.56 ± 74.90 cell/μl vs （200.04 ± 182.79） cell/μl, P 〈 0.01] were found in patients with opportunistic infections than the cases without opportunistic infections. The serum IL-25 was higher in cases with oral candidiasis than the others [（1247.78 ± 1877.48） pg/ml vs （358.09 ± 944.31） pg/ml, P 〈 0.05], while the CD4＋ T-cell count was significantly lower in patients with oral candidiasis than that in patients without candidiasis [（48.56 ± 74.90） cell/μl vs （200.04 ± 182.79） cell/μl, P 〈 0.01]. Serum IL-25 and CD4＋ T-cell count were positive and negative correlated with opportunistic infection and oral candidiasis, respectively. Conclusions IL-25 may play a role in the immunologic mechanism of HIV patients with opportunistic infections. Higher serum IL-25 is probably related to high susceptibility of opportunistic infection and oral candidiasis.

关 键 词：人类免疫缺陷病毒 白细胞介素-25 机会性感染 口腔白色念珠菌 

分 类 号：R512.91[医药卫生—内科学]