替比夫定治疗前后乙型病毒性肝炎后肝硬化患者T淋巴细胞嗜银蛋白含量变化的研究  

Changes of T Lymphocyte Argyrophilic Nucleolar Organizer Region Protein Content in Patients with Hepatitis B Virus Related Cirrhosis before and after Telbivudine Treatment

作　　者：常青山 宫航宇 

机构地区：[1]大连市第六人民医院综合内科,辽宁大连116031

出　　处：《中国医院用药评价与分析》2013年第12期1098-1100,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:通过对替比夫定治疗前后乙型病毒性肝炎后肝硬化患者肝脏功能评分、T淋巴细胞核仁形成区嗜银蛋白(AgNORs)的测定,探讨替比夫定治疗后乙型病毒性肝炎后肝硬化患者的肝功能状况及机体免疫功能的改变。方法:对50例乙型病毒性肝炎后肝硬化患者用替比夫定治疗前及治疗后6个月分别检测肝功能、AgNORs,从而比较使用替比夫定治疗前及治疗6个月后患者AgNORs含量以及Child-Push评分的改变。结果:在使用替比夫定治疗6个月后乙型病毒性肝炎后肝硬化患者肝脏Child-Pugh分级计分显著降低(P<0.05),而AgNORs显著升高(P<0.05)。结论:替比夫定可明显抑制乙型肝炎病毒复制,改善乙型病毒性肝炎后肝硬化患者肝功能,缓解病情,患者在使用替比夫定治疗6个月后T淋巴细胞免疫活性得到明显改善。OBJECTIVE：To evaluate the effects of telbivudine therapy on liver function and immune function in patients with hepatic cirrhosis related to viral hepatitis type B by detecting the liver function score and determining the content of T lymphocyte argyrophilic nucleolar organizer region protein （AgNORs） before and after treatment with telbivudine. METHODS： The liver function and AgNORs in 50 patients with hepatitis B virus related cirrhosis were detected at 0 and 6 months after treatment with telbivudine, with AgNORs content and Child-Push scores compared before and after treatment. RESULTS ： The Child-Push scores in all patients were significantly reduced （ P 〈 0. 05 ） whereas the tlymphocytes AgNORs were significantly increased （ P 〈 0.05 ） at 6 months compared with at 0 month. CONCLUSION： Telbivudine treatment for hepatic cirrhosis resulted in significant inhibition of HBV replication and improvement of the liver function and alleviation of disease and significant improvement in T-lymphocyte immune activity in patients with viral hepatitis type B associated hepatic cirrhosis at 6 months of treatment.

关 键 词：替比夫定 乙型病毒性肝炎 肝硬化 核仁形成区嗜银蛋白 

分 类 号：R965[医药卫生—药理学]