氮端脑钠肽对早产儿动脉导管未闭的诊断价值  

Diagnostic value of N- terminal pro- B- type natriuretic peptide in hemodynamie significant patent ductus arteriosus of premature infants

作　　者：王艳[1] 

机构地区：[1]宁波市妇女儿童医院小儿重症监护病房,浙江宁波315010

出　　处：《中国优生与遗传杂志》2014年第2期105-107,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨氮端脑钠肽(NT-proBNP)在早产儿动脉导管未闭中的诊断价值。方法选择2011年6月至2012年12月我科收治的存在血流动力学改变动脉导管未闭的早产儿20例为病例组。通气无动脉导管未闭的早产儿20例为对照组。用酶联免疫荧光法分别检测两组早产儿第1天、第3天和第6天的血浆NT-proBNP水平。采用受试者操作特性(ROC)曲线评价诊断价值。结果第3天病例组的血浆NT-proBNP水平显著高于对照组,差异有统计学意义(P<0.05)。第3天NT-proBNP的ROC曲线下面积(AUC)为0.892,临界值(cut-off值)2479pmol/l,敏感性为85%,特异性为85%。结论血浆NT-proBNP水平的检测可作为早产儿有血流动力学改变的动脉导管未闭早诊断良好的辅助指标。Objective： to explore the diagnostic value of N -terminal pro- B -type natriuretic peptide （NT- proBNP） in hemo- dynamie significant patent ductus arteriosus （hsPDA） of premature infants. Methods： From June 2011 to December 2012, 20 cases of hsPDA admitted in our hospital of the premature infants as case group, and non PDA from 20 cases of premature infants as control group, every premature infants was tested for the levels of plasma NT -proBNP with enzymelinked immunofluorescent assay （ELIFA） on the first day, the third day and the sixth day, the receiver operating characteristics （ROC） curves were used to evaluate diagnostic value. Results： On the third day, cases of plasma NT- proBNP level is significantly higher than the control group （P 〈0. 05）. The area under the ROC curve for the detection of PDA was significant 0. 892, the cut - off value of plasma NT - proBNP level on day 3 of life was 2479pmol/1, which resulted in 85% sensitivity and 85% sepcificity for diagnosis of PDA. Conclusion： Dectection of NT - proBNP could be utilized as auxiliary indexes in diagonsis of hsPDA in premature infants.

关 键 词：早产儿 动脉导管未闭 氮端脑钠肽 

分 类 号：R722.6[医药卫生—儿科]