生长激素在短方案促排卵治疗中的临床应用  

The clinecal value of growth hormone in GnRHAa short protocol IVF- ET

作　　者：马文敏[1] 吴雅琴[1] 司徒艳球 陈孟循[1] 

机构地区：[1]佛山市妇幼保健院辅助生殖技术中心,广东528000

出　　处：《中国优生与遗传杂志》2014年第2期120-121,126,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探寻生长激素对体外受精-胚胎移植中应用GnRHa短方案促排卵患者的临床价值。方法选择2010年1月至2011年5月我中心IVF-ET治疗中接受GnRHa短方案促排卵的276名患者共299个周期,72个周期有添加生长激素设为研究组,227个周期未添加生长激素设为对照组。分析比较两组一般情况、治疗情况及临床结局。结果研究组Gn用药天数略低于对照组,但Gn平均用量稍高于对照组,差异有统计学意义。两组之间获卵数、成熟卵子数、受精率、取消周期率、妊娠率均无显著性差异。活产率方面,对照组显著高于对照组。结论对于卵巢储备功能降低患者应用GnRHa短方案,添加生长激素虽不能改善其妊娠率,但能显著提高活产率。Objective： To explore the clinical value of growth hormone in GnRHa short protocol in vitro fertilization and embryo transfer. Methods： Retrospective analysis the patients date who received GnRHa in IVF - ET treatment with short program promoting ovulation from our center between January 2010 and May 2010, we divided two grops, the 72 cycles added growth hormones was set as research group, the other 22？ cycles was set as control group. The general situation, treatment and clinical outcomes were compared Results ： the application days of Gn in the research group slightly lower than in the control group, but the Gn average dosage is slightly higher than the control group and the difference has statistical significance. Compared the two groups egg number, number of mature eggs, fertilization rate, cancellation rate and pregnancy rates were no significant differences, but the live birth rate is significantly high- er than the control group. Conclusion： For patients with poor ovarian reserve using GnRHa short protocol, adding growth hormone does not improve the pregnancy rate, but can significantly improve the live birth rate.

关 键 词：生长激素 短方案 体外受精-胚胎移植促排卵 卵巢低反应 

分 类 号：R714.8[医药卫生—妇产科学]